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Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors.
Xiang HY, Wang X, Chen YH, Zhang X, Tan C, Wang Y, Su Y, Gao ZW, Chen XY, Xiong B, Gao ZB, Chen Y, Ding J, Meng LH, Yang CH. Xiang HY, et al. Among authors: wang x, wang y. Eur J Med Chem. 2021 Jan 1;209:112913. doi: 10.1016/j.ejmech.2020.112913. Epub 2020 Oct 21. Eur J Med Chem. 2021. PMID: 33109399
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