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AMPK regulates metabolism and survival in response to ionizing radiation.
Zannella VE, Cojocari D, Hilgendorf S, Vellanki RN, Chung S, Wouters BG, Koritzinsky M. Zannella VE, et al. Among authors: wouters bg. Radiother Oncol. 2011 Jun;99(3):293-9. doi: 10.1016/j.radonc.2011.05.049. Epub 2011 Jun 27. Radiother Oncol. 2011. PMID: 21715037
Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs.
Hunter FW, Young RJ, Shalev Z, Vellanki RN, Wang J, Gu Y, Joshi N, Sreebhavan S, Weinreb I, Goldstein DP, Moffat J, Ketela T, Brown KR, Koritzinsky M, Solomon B, Rischin D, Wilson WR, Wouters BG. Hunter FW, et al. Among authors: wouters bg. Cancer Res. 2015 Oct 1;75(19):4211-23. doi: 10.1158/0008-5472.CAN-15-1107. Epub 2015 Aug 21. Cancer Res. 2015. PMID: 26297733
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG. Banh RS, et al. Among authors: wouters bg. Nat Cell Biol. 2016 Jul;18(7):803-813. doi: 10.1038/ncb3376. Epub 2016 Jun 20. Nat Cell Biol. 2016. PMID: 27323329 Free PMC article.
MATE2 Expression Is Associated with Cancer Cell Response to Metformin.
Chowdhury S, Yung E, Pintilie M, Muaddi H, Chaib S, Yeung M, Fusciello M, Sykes J, Pitcher B, Hagenkort A, McKee T, Vellanki R, Chen E, Bristow RG, Wouters BG, Koritzinsky M. Chowdhury S, et al. Among authors: wouters bg. PLoS One. 2016 Dec 13;11(12):e0165214. doi: 10.1371/journal.pone.0165214. eCollection 2016. PLoS One. 2016. PMID: 27959931 Free PMC article.
Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.
Leung E, Cairns RA, Chaudary N, Vellanki RN, Kalliomaki T, Moriyama EH, Mujcic H, Wilson BC, Wouters BG, Hill R, Milosevic M. Leung E, et al. Among authors: wouters bg. BMC Cancer. 2017 Jun 15;17(1):418. doi: 10.1186/s12885-017-3402-6. BMC Cancer. 2017. PMID: 28619042 Free PMC article.
234 results