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African Swine Fever Virus Georgia Isolate Harboring Deletions of MGF360 and MGF505 Genes Is Attenuated in Swine and Confers Protection against Challenge with Virulent Parental Virus.
O'Donnell V, Holinka LG, Gladue DP, Sanford B, Krug PW, Lu X, Arzt J, Reese B, Carrillo C, Risatti GR, Borca MV. O'Donnell V, et al. Among authors: krug pw. J Virol. 2015 Jun;89(11):6048-56. doi: 10.1128/JVI.00554-15. Epub 2015 Mar 25. J Virol. 2015. PMID: 25810553 Free PMC article.
The progressive adaptation of a georgian isolate of African swine fever virus to vero cells leads to a gradual attenuation of virulence in swine corresponding to major modifications of the viral genome.
Krug PW, Holinka LG, O'Donnell V, Reese B, Sanford B, Fernandez-Sainz I, Gladue DP, Arzt J, Rodriguez L, Risatti GR, Borca MV. Krug PW, et al. J Virol. 2015 Feb;89(4):2324-32. doi: 10.1128/JVI.03250-14. Epub 2014 Dec 10. J Virol. 2015. PMID: 25505073 Free PMC article.
African Swine Fever Virus Georgia 2007 with a Deletion of Virulence-Associated Gene 9GL (B119L), when Administered at Low Doses, Leads to Virus Attenuation in Swine and Induces an Effective Protection against Homologous Challenge.
O'Donnell V, Holinka LG, Krug PW, Gladue DP, Carlson J, Sanford B, Alfano M, Kramer E, Lu Z, Arzt J, Reese B, Carrillo C, Risatti GR, Borca MV. O'Donnell V, et al. Among authors: krug pw. J Virol. 2015 Aug;89(16):8556-66. doi: 10.1128/JVI.00969-15. Epub 2015 Jun 10. J Virol. 2015. PMID: 26063424 Free PMC article.
African swine fever virus Georgia isolate harboring deletions of 9GL and MGF360/505 genes is highly attenuated in swine but does not confer protection against parental virus challenge.
O'Donnell V, Holinka LG, Sanford B, Krug PW, Carlson J, Pacheco JM, Reese B, Risatti GR, Gladue DP, Borca MV. O'Donnell V, et al. Among authors: krug pw. Virus Res. 2016 Aug 2;221:8-14. doi: 10.1016/j.virusres.2016.05.014. Epub 2016 May 12. Virus Res. 2016. PMID: 27182007
Simultaneous Deletion of the 9GL and UK Genes from the African Swine Fever Virus Georgia 2007 Isolate Offers Increased Safety and Protection against Homologous Challenge.
O'Donnell V, Risatti GR, Holinka LG, Krug PW, Carlson J, Velazquez-Salinas L, Azzinaro PA, Gladue DP, Borca MV. O'Donnell V, et al. Among authors: krug pw. J Virol. 2016 Dec 16;91(1):e01760-16. doi: 10.1128/JVI.01760-16. Print 2017 Jan 1. J Virol. 2016. PMID: 27795430 Free PMC article.
31 results