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Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.
Arulanandam R, Batenchuk C, Varette O, Zakaria C, Garcia V, Forbes NE, Davis C, Krishnan R, Karmacharya R, Cox J, Sinha A, Babawy A, Waite K, Weinstein E, Falls T, Chen A, Hamill J, De Silva N, Conrad DP, Atkins H, Garson K, Ilkow C, Kærn M, Vanderhyden B, Sonenberg N, Alain T, Le Boeuf F, Bell JC, Diallo JS. Arulanandam R, et al. Among authors: alain t. Nat Commun. 2015 Mar 30;6:6410. doi: 10.1038/ncomms7410. Nat Commun. 2015. PMID: 25817275 Free article.
The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis.
Parsyan A, Shahbazian D, Martineau Y, Petroulakis E, Alain T, Larsson O, Mathonnet G, Tettweiler G, Hellen CU, Pestova TV, Svitkin YV, Sonenberg N. Parsyan A, et al. Among authors: alain t. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22217-22. doi: 10.1073/pnas.0909773106. Epub 2009 Dec 11. Proc Natl Acad Sci U S A. 2009. PMID: 20018725 Free PMC article.
mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N. Dowling RJ, et al. Among authors: alain t. Science. 2010 May 28;328(5982):1172-6. doi: 10.1126/science.1187532. Science. 2010. PMID: 20508131 Free PMC article.
Virus-tumor interactome screen reveals ER stress response can reprogram resistant cancers for oncolytic virus-triggered caspase-2 cell death.
Mahoney DJ, Lefebvre C, Allan K, Brun J, Sanaei CA, Baird S, Pearce N, Grönberg S, Wilson B, Prakesh M, Aman A, Isaac M, Mamai A, Uehling D, Al-Awar R, Falls T, Alain T, Stojdl DF. Mahoney DJ, et al. Among authors: alain t. Cancer Cell. 2011 Oct 18;20(4):443-56. doi: 10.1016/j.ccr.2011.09.005. Cancer Cell. 2011. PMID: 22014571 Free article.
123 results