Lave T - Search Results

1

Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis.

Benay S, Meille C, Kustermann S, Walter I, Walz A, Gonsard PA, Pietilae E, Kratochwil N, Iliadis A, Roth A, Lave T. Benay S, et al. Among authors: lave t. J Pharmacokinet Pharmacodyn. 2015 Jun;42(3):275-85. doi: 10.1007/s10928-015-9415-3. Epub 2015 Mar 31. J Pharmacokinet Pharmacodyn. 2015. PMID: 25822652

2

Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: influence of time between substrate and inducer administration.

Baneyx G, Parrott N, Meille C, Iliadis A, Lavé T. Baneyx G, et al. Among authors: lave t. Eur J Pharm Sci. 2014 Jun 2;56:1-15. doi: 10.1016/j.ejps.2014.02.002. Epub 2014 Feb 12. Eur J Pharm Sci. 2014. PMID: 24530864

3

Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.

Kratochwil NA, Meille C, Fowler S, Klammers F, Ekiciler A, Molitor B, Simon S, Walter I, McGinnis C, Walther J, Leonard B, Triyatni M, Javanbakht H, Funk C, Schuler F, Lavé T, Parrott NJ. Kratochwil NA, et al. Among authors: lave t. AAPS J. 2017 Mar;19(2):534-550. doi: 10.1208/s12248-016-0019-7. Epub 2017 Jan 3. AAPS J. 2017. PMID: 28050713 Free article.

4

Translational PK/PD modeling to increase probability of success in drug discovery and early development.

Lavé T, Caruso A, Parrott N, Walz A. Lavé T, et al. Drug Discov Today Technol. 2016 Sep-Dec;21-22:27-34. doi: 10.1016/j.ddtec.2016.11.005. Epub 2016 Dec 10. Drug Discov Today Technol. 2016. PMID: 27978984 Review.

5

Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.

Caruso A, Frances N, Meille C, Greiter-Wilke A, Hillebrecht A, Lavé T. Caruso A, et al. Among authors: lave t. J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):73-85. doi: 10.1016/j.vascn.2014.05.004. Epub 2014 May 28. J Pharmacol Toxicol Methods. 2014. PMID: 24879942

6

Influence of molecular size on tissue distribution of antibody fragments.

Li Z, Krippendorff BF, Sharma S, Walz AC, Lavé T, Shah DK. Li Z, et al. Among authors: lave t. MAbs. 2016;8(1):113-9. doi: 10.1080/19420862.2015.1111497. Epub 2015 Oct 23. MAbs. 2016. PMID: 26496429 Free PMC article.

7

Recent developments in using mechanistic cardiac modelling for drug safety evaluation.

Davies MR, Wang K, Mirams GR, Caruso A, Noble D, Walz A, Lavé T, Schuler F, Singer T, Polonchuk L. Davies MR, et al. Among authors: lave t. Drug Discov Today. 2016 Jun;21(6):924-38. doi: 10.1016/j.drudis.2016.02.003. Epub 2016 Feb 15. Drug Discov Today. 2016. PMID: 26891981 Free PMC article. Review.

8

PKPD modeling of acquired resistance to anti-cancer drug treatment.

Eigenmann MJ, Frances N, Lavé T, Walz AC. Eigenmann MJ, et al. Among authors: lave t. J Pharmacokinet Pharmacodyn. 2017 Dec;44(6):617-630. doi: 10.1007/s10928-017-9553-x. Epub 2017 Oct 31. J Pharmacokinet Pharmacodyn. 2017. PMID: 29090407 Free PMC article.

9

A novel strategy for physiologically based predictions of human pharmacokinetics.

Jones HM, Parrott N, Jorga K, Lavé T. Jones HM, et al. Among authors: lave t. Clin Pharmacokinet. 2006;45(5):511-42. doi: 10.2165/00003088-200645050-00006. Clin Pharmacokinet. 2006. PMID: 16640456

10

Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.

Jones HM, Parrott N, Ohlenbusch G, Lavé T. Jones HM, et al. Among authors: lave t. Clin Pharmacokinet. 2006;45(12):1213-26. doi: 10.2165/00003088-200645120-00006. Clin Pharmacokinet. 2006. PMID: 17112297

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