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LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.
Sun G, da Silva Xavier G, Gorman T, Priest C, Solomou A, Hodson DJ, Foretz M, Viollet B, Herrera PL, Parker H, Reimann F, Gribble FM, Migrenne S, Magnan C, Marley A, Rutter GA. Sun G, et al. Among authors: herrera pl. Mol Metab. 2015 Jan 31;4(4):277-86. doi: 10.1016/j.molmet.2015.01.006. eCollection 2015 Apr. Mol Metab. 2015. PMID: 25830091 Free PMC article.
PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice.
Iglesias J, Barg S, Vallois D, Lahiri S, Roger C, Yessoufou A, Pradevand S, McDonald A, Bonal C, Reimann F, Gribble F, Debril MB, Metzger D, Chambon P, Herrera P, Rutter GA, Prentki M, Thorens B, Wahli W. Iglesias J, et al. J Clin Invest. 2012 Nov;122(11):4105-17. doi: 10.1172/JCI42127. Epub 2012 Oct 24. J Clin Invest. 2012. PMID: 23093780 Free PMC article.
Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.
Semplici F, Mondragon A, Macintyre B, Madeyski-Bengston K, Persson-Kry A, Barr S, Ramne A, Marley A, McGinty J, French P, Soedling H, Yokosuka R, Gaitan J, Lang J, Migrenne-Li S, Philippe E, Herrera PL, Magnan C, da Silva Xavier G, Rutter GA. Semplici F, et al. Among authors: herrera pl. Diabetologia. 2016 Sep;59(9):1938-47. doi: 10.1007/s00125-016-4025-1. Epub 2016 Jun 24. Diabetologia. 2016. PMID: 27338626 Free PMC article.
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. Chae H, et al. Among authors: herrera pl. Mol Metab. 2020 Dec;42:101071. doi: 10.1016/j.molmet.2020.101071. Epub 2020 Sep 5. Mol Metab. 2020. PMID: 32896668 Free PMC article.
Insulin signaling in alpha cells modulates glucagon secretion in vivo.
Kawamori D, Kurpad AJ, Hu J, Liew CW, Shih JL, Ford EL, Herrera PL, Polonsky KS, McGuinness OP, Kulkarni RN. Kawamori D, et al. Among authors: herrera pl. Cell Metab. 2009 Apr;9(4):350-61. doi: 10.1016/j.cmet.2009.02.007. Cell Metab. 2009. PMID: 19356716 Free PMC article.
116 results