François-Moutal L - Search Results

1

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

Moutal A, François-Moutal L, Perez-Miller S, Cottier K, Chew LA, Yeon SK, Dai J, Park KD, Khanna M, Khanna R. Moutal A, et al. Mol Neurobiol. 2016 Apr;53(3):1959-1976. doi: 10.1007/s12035-015-9141-2. Epub 2015 Apr 7. Mol Neurobiol. 2016. PMID: 25846820

2

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.

Wilson SM, Moutal A, Melemedjian OK, Wang Y, Ju W, François-Moutal L, Khanna M, Khanna R. Wilson SM, et al. Front Cell Neurosci. 2014 Jul 24;8:196. doi: 10.3389/fncel.2014.00196. eCollection 2014. Front Cell Neurosci. 2014. PMID: 25104922 Free PMC article.

3

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides.

Moutal A, François-Moutal L, Brittain JM, Khanna M, Khanna R. Moutal A, et al. Front Cell Neurosci. 2015 Jan 26;8:471. doi: 10.3389/fncel.2014.00471. eCollection 2014. Front Cell Neurosci. 2015. PMID: 25674050 Free PMC article.

4

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.

François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R. François-Moutal L, et al. Pain. 2015 Jul;156(7):1247-1264. doi: 10.1097/j.pain.0000000000000147. Pain. 2015. PMID: 25782368 Free PMC article.

5

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R. Moutal A, et al. Br J Pharmacol. 2018 Jun;175(12):2244-2260. doi: 10.1111/bph.13737. Epub 2017 Mar 17. Br J Pharmacol. 2018. PMID: 28161890 Free PMC article.

6

A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.

Dustrude ET, Perez-Miller S, François-Moutal L, Moutal A, Khanna M, Khanna R. Dustrude ET, et al. Channels (Austin). 2017 Jul 4;11(4):316-328. doi: 10.1080/19336950.2017.1299838. Epub 2017 Feb 28. Channels (Austin). 2017. PMID: 28277940 Free PMC article.

7

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.

Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, Porreca F, Khanna R. Moutal A, et al. Pain. 2017 Dec;158(12):2301-2319. doi: 10.1097/j.pain.0000000000001002. Pain. 2017. PMID: 28809766 Free PMC article.

8

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.

François-Moutal L, Dustrude ET, Wang Y, Brustovetsky T, Dorame A, Ju W, Moutal A, Perez-Miller S, Brustovetsky N, Gokhale V, Khanna M, Khanna R. François-Moutal L, et al. Pain. 2018 Oct;159(10):2115-2127. doi: 10.1097/j.pain.0000000000001294. Pain. 2018. PMID: 29847471 Free PMC article.

9

Chemical shift perturbation mapping of the Ubc9-CRMP2 interface identifies a pocket in CRMP2 amenable for allosteric modulation of Nav1.7 channels.

François-Moutal L, Scott DD, Perez-Miller S, Gokhale V, Khanna M, Khanna R. François-Moutal L, et al. Channels (Austin). 2018;12(1):219-227. doi: 10.1080/19336950.2018.1491244. Epub 2018 Aug 6. Channels (Austin). 2018. PMID: 30081699 Free PMC article.

10

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M. François-Moutal L, et al. ACS Chem Biol. 2018 Oct 19;13(10):3000-3010. doi: 10.1021/acschembio.8b00745. Epub 2018 Sep 6. ACS Chem Biol. 2018. PMID: 30141626 Free PMC article.

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