Imai YN - Search Results

1

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I.

Aikawa K, Miyawaki T, Hitaka T, Imai YN, Hara T, Miyazaki J, Yamaoka M, Kusaka M, Kanzaki N, Tasaka A, Shiraishi M, Yamamoto S. Aikawa K, et al. Among authors: imai yn. Bioorg Med Chem. 2015 May 15;23(10):2568-78. doi: 10.1016/j.bmc.2015.03.032. Epub 2015 Mar 19. Bioorg Med Chem. 2015. PMID: 25862209

2

Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives.

Asano M, Hitaka T, Imada T, Yamada M, Morimoto M, Shinohara H, Hara T, Yamaoka M, Santou T, Nakayama M, Imai Y, Habuka N, Yano J, Wilson K, Fujita H, Hasuoka A. Asano M, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):1897-1901. doi: 10.1016/j.bmcl.2017.03.038. Epub 2017 Mar 21. Bioorg Med Chem Lett. 2017. PMID: 28363748

3

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists.

Miwatashi S, Arikawa Y, Matsumoto T, Uga K, Kanzaki N, Imai YN, Ohkawa S. Miwatashi S, et al. Among authors: imai yn. Chem Pharm Bull (Tokyo). 2008 Aug;56(8):1126-37. doi: 10.1248/cpb.56.1126. Chem Pharm Bull (Tokyo). 2008. PMID: 18670113 Free article.

4

Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.

Tanaka Y, Aikawa K, Nishida G, Homma M, Sogabe S, Igaki S, Hayano Y, Sameshima T, Miyahisa I, Kawamoto T, Tawada M, Imai Y, Inazuka M, Cho N, Imaeda Y, Ishikawa T. Tanaka Y, et al. J Med Chem. 2013 Dec 12;56(23):9635-45. doi: 10.1021/jm401170c. Epub 2013 Dec 2. J Med Chem. 2013. PMID: 24215352

5

A mutation in beta-tubulin and a sustained dependence on androgen receptor signalling in a newly established docetaxel-resistant prostate cancer cell line.

Hara T, Ushio K, Nishiwaki M, Kouno J, Araki H, Hikichi Y, Hattori M, Imai Y, Yamaoka M. Hara T, et al. Cell Biol Int. 2010 Jan 25;34(2):177-84. doi: 10.1042/CBI20090030. Cell Biol Int. 2010. PMID: 19947927

6

Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-go-Related Gene (hERG) Liabilities.

Sakauchi N, Kohara Y, Sato A, Suzaki T, Imai Y, Okabe Y, Imai S, Saikawa R, Nagabukuro H, Kuno H, Fujita H, Kamo I, Yoshida M. Sakauchi N, et al. J Med Chem. 2016 Apr 14;59(7):2989-3002. doi: 10.1021/acs.jmedchem.5b01528. Epub 2016 Mar 17. J Med Chem. 2016. PMID: 26954848

7

Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities.

Kasai S, Kamata M, Masada S, Kunitomo J, Kamaura M, Okawa T, Takami K, Ogino H, Nakano Y, Ashina S, Watanabe K, Kaisho T, Imai YN, Ryu S, Nakayama M, Nagisa Y, Takekawa S, Kato K, Murata T, Suzuki N, Ishihara Y. Kasai S, et al. Among authors: imai yn. J Med Chem. 2012 May 10;55(9):4336-51. doi: 10.1021/jm300167z. Epub 2012 Apr 23. J Med Chem. 2012. PMID: 22490048

8

Synthesis of a novel series of tricyclic indan derivatives as melatonin receptor agonists.

Uchikawa O, Fukatsu K, Tokunoh R, Kawada M, Matsumoto K, Imai Y, Hinuma S, Kato K, Nishikawa H, Hirai K, Miyamoto M, Ohkawa S. Uchikawa O, et al. J Med Chem. 2002 Sep 12;45(19):4222-39. doi: 10.1021/jm0201159. J Med Chem. 2002. PMID: 12213063

9

The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel.

Ryu S, Imai YN, Oiki S. Ryu S, et al. Among authors: imai yn. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3848-51. doi: 10.1016/j.bmcl.2013.04.074. Epub 2013 May 7. Bioorg Med Chem Lett. 2013. PMID: 23711922 Free article.

10

Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists.

Sato A, Fukase Y, Kono M, Ochida A, Oda T, Sasaki Y, Ishii N, Tomata Y, Fukumoto S, Imai YN, Uga K, Shibata A, Yamasaki M, Nakagawa H, Shirasaki M, Skene R, Hoffman I, Sang BC, Snell G, Shirai J, Yamamoto S. Sato A, et al. Among authors: imai yn. ChemMedChem. 2019 Nov 20;14(22):1917-1932. doi: 10.1002/cmdc.201900416. Epub 2019 Nov 5. ChemMedChem. 2019. PMID: 31659845

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