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Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration-proliferation dichotomy.
Bhandari D, Lopez-Sanchez I, To A, Lo IC, Aznar N, Leyme A, Gupta V, Niesman I, Maddox AL, Garcia-Marcos M, Farquhar MG, Ghosh P. Bhandari D, et al. Among authors: lo ic. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4874-83. doi: 10.1073/pnas.1514157112. Epub 2015 Aug 18. Proc Natl Acad Sci U S A. 2015. PMID: 26286990 Free PMC article.
GIV/Girdin activates Gαi and inhibits Gαs via the same motif.
Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P. Gupta V, et al. Among authors: lo ic. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12. Proc Natl Acad Sci U S A. 2016. PMID: 27621449 Free PMC article.
A circuit for secretion-coupled cellular autonomy in multicellular eukaryotic cells.
Qiao L, Sinha S, Abd El-Hafeez AA, Lo IC, Midde KK, Ngo T, Aznar N, Lopez-Sanchez I, Gupta V, Farquhar MG, Rangamani P, Ghosh P. Qiao L, et al. Among authors: lo ic. Mol Syst Biol. 2023 Apr 12;19(4):e11127. doi: 10.15252/msb.202211127. Epub 2023 Mar 1. Mol Syst Biol. 2023. PMID: 36856068 Free PMC article.
18 results