Leduc R - Search Results

1

Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling.

Zoratti GL, Tanabe LM, Varela FA, Murray AS, Bergum C, Colombo É, Lang JE, Molinolo AA, Leduc R, Marsault E, Boerner J, List K. Zoratti GL, et al. Among authors: leduc r. Nat Commun. 2015 Apr 15;6:6776. doi: 10.1038/ncomms7776. Nat Commun. 2015. PMID: 25873032 Free PMC article.

2

Inhibition of human matriptase by eglin c variants.

Désilets A, Longpré JM, Beaulieu ME, Leduc R. Désilets A, et al. Among authors: leduc r. FEBS Lett. 2006 Apr 17;580(9):2227-32. doi: 10.1016/j.febslet.2006.03.030. Epub 2006 Mar 20. FEBS Lett. 2006. PMID: 16566926 Free article.

3

Elucidation of the structure-activity relationships of apelin: influence of unnatural amino acids on binding, signaling, and plasma stability.

Murza A, Parent A, Besserer-Offroy E, Tremblay H, Karadereye F, Beaudet N, Leduc R, Sarret P, Marsault É. Murza A, et al. Among authors: leduc r. ChemMedChem. 2012 Feb 6;7(2):318-25. doi: 10.1002/cmdc.201100492. Epub 2011 Dec 13. ChemMedChem. 2012. PMID: 22170700

4

Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.

Beaulieu A, Gravel É, Cloutier A, Marois I, Colombo É, Désilets A, Verreault C, Leduc R, Marsault É, Richter MV. Beaulieu A, et al. Among authors: leduc r. J Virol. 2013 Apr;87(8):4237-51. doi: 10.1128/JVI.03005-12. Epub 2013 Jan 30. J Virol. 2013. PMID: 23365447 Free PMC article.

5

Design and synthesis of potent, selective inhibitors of matriptase.

Colombo E, Désilets A, Duchêne D, Chagnon F, Najmanovich R, Leduc R, Marsault E. Colombo E, et al. Among authors: leduc r. ACS Med Chem Lett. 2012 Apr 11;3(7):530-4. doi: 10.1021/ml3000534. eCollection 2012 Jul 12. ACS Med Chem Lett. 2012. PMID: 24900505 Free PMC article.

6

Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2.

Duchêne D, Colombo E, Désilets A, Boudreault PL, Leduc R, Marsault E, Najmanovich R. Duchêne D, et al. Among authors: leduc r. J Med Chem. 2014 Dec 11;57(23):10198-204. doi: 10.1021/jm5015633. Epub 2014 Nov 21. J Med Chem. 2014. PMID: 25387268

7

C-Terminal modifications of apelin-13 significantly change ligand binding, receptor signaling, and hypotensive action.

Murza A, Besserer-Offroy É, Côté J, Bérubé P, Longpré JM, Dumaine R, Lesur O, Auger-Messier M, Leduc R, Sarret P, Marsault É. Murza A, et al. Among authors: leduc r. J Med Chem. 2015 Mar 12;58(5):2431-40. doi: 10.1021/jm501916k. Epub 2015 Feb 24. J Med Chem. 2015. PMID: 25668242

8

Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions.

Murza A, Sainsily X, Coquerel D, Côté J, Marx P, Besserer-Offroy É, Longpré JM, Lainé J, Reversade B, Salvail D, Leduc R, Dumaine R, Lesur O, Auger-Messier M, Sarret P, Marsault É. Murza A, et al. Among authors: leduc r. J Med Chem. 2016 Apr 14;59(7):2962-72. doi: 10.1021/acs.jmedchem.5b01549. Epub 2016 Mar 30. J Med Chem. 2016. PMID: 26986036

9

Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists.

Mona CE, Besserer-Offroy É, Cabana J, Lefrançois M, Boulais PE, Lefebvre MR, Leduc R, Lavigne P, Heveker N, Marsault É, Escher E. Mona CE, et al. Among authors: leduc r. J Med Chem. 2016 Aug 25;59(16):7512-24. doi: 10.1021/acs.jmedchem.6b00566. Epub 2016 Aug 11. J Med Chem. 2016. PMID: 27434274

10

Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer.

Zoratti GL, Tanabe LM, Hyland TE, Duhaime MJ, Colombo É, Leduc R, Marsault E, Johnson MD, Lin CY, Boerner J, Lang JE, List K. Zoratti GL, et al. Among authors: leduc r. Oncotarget. 2016 Sep 6;7(36):58162-58173. doi: 10.18632/oncotarget.11262. Oncotarget. 2016. PMID: 27528224 Free PMC article.

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