Medema JP - Search Results

1

Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification.

Potze L, Di Franco S, Grandela C, Pras-Raves ML, Picavet DI, van Veen HA, van Lenthe H, Mullauer FB, van der Wel NN, Luyf A, van Kampen AH, Kemp S, Everts V, Kessler JH, Vaz FM, Medema JP. Potze L, et al. Among authors: medema jp. Oncogene. 2016 Jan 28;35(4):427-37. doi: 10.1038/onc.2015.102. Epub 2015 Apr 20. Oncogene. 2016. PMID: 25893306

2

Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa.

Medema JP, de Vries-Smits AM, Bos JL. Medema JP, et al. Oncogene. 1995 Aug 17;11(4):757-62. Oncogene. 1995. PMID: 7544452

3

Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types.

Kessler JH, Mullauer FB, de Roo GM, Medema JP. Kessler JH, et al. Among authors: medema jp. Cancer Lett. 2007 Jun 18;251(1):132-45. doi: 10.1016/j.canlet.2006.11.003. Epub 2006 Dec 13. Cancer Lett. 2007. PMID: 17169485

4

Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion.

Mullauer FB, Kessler JH, Medema JP. Mullauer FB, et al. Among authors: medema jp. Apoptosis. 2009 Feb;14(2):191-202. doi: 10.1007/s10495-008-0290-x. Apoptosis. 2009. PMID: 19115109

5

Betulin is a potent anti-tumor agent that is enhanced by cholesterol.

Mullauer FB, Kessler JH, Medema JP. Mullauer FB, et al. Among authors: medema jp. PLoS One. 2009;4(4):e1. doi: 10.1371/journal.pone.0005361. Epub 2009 Apr 28. PLoS One. 2009. PMID: 19399186 Free PMC article.

6

Betulinic acid, a natural compound with potent anticancer effects.

Mullauer FB, Kessler JH, Medema JP. Mullauer FB, et al. Among authors: medema jp. Anticancer Drugs. 2010 Mar;21(3):215-27. doi: 10.1097/CAD.0b013e3283357c62. Anticancer Drugs. 2010. PMID: 20075711 Review.

7

Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity.

Mullauer FB, van Bloois L, Daalhuisen JB, Ten Brink MS, Storm G, Medema JP, Schiffelers RM, Kessler JH. Mullauer FB, et al. Among authors: medema jp. Anticancer Drugs. 2011 Mar;22(3):223-33. doi: 10.1097/CAD.0b013e3283421035. Anticancer Drugs. 2011. PMID: 21263311

8

Molecular identification and targeting of colorectal cancer stem cells.

Kemper K, Grandela C, Medema JP. Kemper K, et al. Among authors: medema jp. Oncotarget. 2010 Oct;1(6):387-395. doi: 10.18632/oncotarget.173. Oncotarget. 2010. PMID: 21311095 Free PMC article. Review.

9

Targeting colorectal cancer stem cells with inducible caspase-9.

Kemper K, Rodermond H, Colak S, Grandela C, Medema JP. Kemper K, et al. Among authors: medema jp. Apoptosis. 2012 May;17(5):528-37. doi: 10.1007/s10495-011-0692-z. Apoptosis. 2012. PMID: 22223359 Free PMC article.

10

Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme.

Borovski T, Beke P, van Tellingen O, Rodermond HM, Verhoeff JJ, Lascano V, Daalhuisen JB, Medema JP, Sprick MR. Borovski T, et al. Among authors: medema jp. Oncogene. 2013 Mar 21;32(12):1539-48. doi: 10.1038/onc.2012.172. Epub 2012 May 21. Oncogene. 2013. PMID: 22614016

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