Unge J - Search Results

1

Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV-1 Protease Inhibitors (II).

Hohlfeld K, Wegner JK, Kesteleyn B, Linclau B, Unge J. Hohlfeld K, et al. Among authors: unge j. J Med Chem. 2015 May 14;58(9):4029-38. doi: 10.1021/acs.jmedchem.5b00358. Epub 2015 Apr 30. J Med Chem. 2015. PMID: 25897791

2

Synthesis, X-ray analysis, and biological evaluation of a new class of stereopure lactam-based HIV-1 protease inhibitors.

Wu X, Ohrngren P, Joshi AA, Trejos A, Persson M, Arvela RK, Wallberg H, Vrang L, Rosenquist A, Samuelsson BB, Unge J, Larhed M. Wu X, et al. Among authors: unge j. J Med Chem. 2012 Mar 22;55(6):2724-36. doi: 10.1021/jm201620t. Epub 2012 Mar 13. J Med Chem. 2012. PMID: 22376008 Free PMC article.

3

Design and synthesis of P1-P3 macrocyclic tertiary-alcohol-comprising HIV-1 protease inhibitors.

Joshi A, Véron JB, Unge J, Rosenquist Å, Wallberg H, Samuelsson B, Hallberg A, Larhed M. Joshi A, et al. Among authors: unge j. J Med Chem. 2013 Nov 27;56(22):8999-9007. doi: 10.1021/jm400811d. Epub 2013 Nov 11. J Med Chem. 2013. PMID: 24160253 Free article.

4

Two-carbon-elongated HIV-1 protease inhibitors with a tertiary-alcohol-containing transition-state mimic.

Wu X, Ohrngren P, Ekegren JK, Unge J, Unge T, Wallberg H, Samuelsson B, Hallberg A, Larhed M. Wu X, et al. Among authors: unge j, unge t. J Med Chem. 2008 Feb 28;51(4):1053-7. doi: 10.1021/jm070680h. Epub 2008 Jan 24. J Med Chem. 2008. PMID: 18215014

5

Synthesis of P1'-functionalized macrocyclic transition-state mimicking HIV-1 protease inhibitors encompassing a tertiary alcohol.

De Rosa M, Unge J, Motwani HV, Rosenquist Å, Vrang L, Wallberg H, Larhed M. De Rosa M, et al. Among authors: unge j. J Med Chem. 2014 Aug 14;57(15):6444-57. doi: 10.1021/jm500434q. Epub 2014 Aug 1. J Med Chem. 2014. PMID: 25054811

6

Difluoromethylbenzoxazole pyrimidine thioether derivatives: a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.

Boyer J, Arnoult E, Médebielle M, Guillemont J, Unge J, Jochmans D. Boyer J, et al. Among authors: unge j. J Med Chem. 2011 Dec 8;54(23):7974-85. doi: 10.1021/jm200766b. Epub 2011 Nov 4. J Med Chem. 2011. PMID: 22017513

7

A mutant form of the ribosomal protein L1 reveals conformational flexibility.

Unge J, Al-Karadaghi S, Liljas A, Jonsson BH, Eliseikina I, Ossina N, Nevskaya N, Fomenkova N, Garber M, Nikonov S. Unge J, et al. FEBS Lett. 1997 Jul 7;411(1):53-9. doi: 10.1016/s0014-5793(97)00611-x. FEBS Lett. 1997. PMID: 9247141 Free article.

8

The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance.

Unge J, berg A, Al-Kharadaghi S, Nikulin A, Nikonov S, Davydova N, Nevskaya N, Garber M, Liljas A. Unge J, et al. Structure. 1998 Dec 15;6(12):1577-86. doi: 10.1016/s0969-2126(98)00155-5. Structure. 1998. PMID: 9862810 Free article.

9

Potential for dramatic improvement in sequence alignment against structures of remote homologous proteins by extracting structural information from multiple structure alignment.

Zhang Z, Lindstam M, Unge J, Peterson C, Lu G. Zhang Z, et al. Among authors: unge j. J Mol Biol. 2003 Sep 5;332(1):127-42. doi: 10.1016/s0022-2836(03)00858-1. J Mol Biol. 2003. PMID: 12946352

10

The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms.

Hasan M, Khakzad H, Happonen L, Sundin A, Unge J, Mueller U, Malmström J, Westergren-Thorsson G, Malmström L, Ellervik U, Malmström A, Tykesson E. Hasan M, et al. Among authors: unge j. Chem Sci. 2020 Dec 8;12(5):1869-1885. doi: 10.1039/d0sc05971d. eCollection 2021 Feb 7. Chem Sci. 2020. PMID: 33815739 Free PMC article.

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