Yang L - Search Results

1

Development and validation of receptor occupancy pharmacodynamic assays used in the clinical development of the monoclonal antibody vedolizumab.

Wyant T, Estevam J, Yang L, Rosario M. Wyant T, et al. Among authors: yang l. Cytometry B Clin Cytom. 2016 Mar;90(2):168-76. doi: 10.1002/cyto.b.21236. Epub 2015 Apr 27. Cytometry B Clin Cytom. 2016. PMID: 25908521 Free article. Clinical Trial.

2

The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases.

Soler D, Chapman T, Yang LL, Wyant T, Egan R, Fedyk ER. Soler D, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):864-75. doi: 10.1124/jpet.109.153973. Epub 2009 Jun 9. J Pharmacol Exp Ther. 2009. PMID: 19509315

3

Exclusive antagonism of the α4 β7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates.

Fedyk ER, Wyant T, Yang LL, Csizmadia V, Burke K, Yang H, Kadambi VJ. Fedyk ER, et al. Inflamm Bowel Dis. 2012 Nov;18(11):2107-19. doi: 10.1002/ibd.22940. Epub 2012 Mar 14. Inflamm Bowel Dis. 2012. PMID: 22419649

4

Antagonizing the α4β1 integrin, but not α4β7, inhibits leukocytic infiltration of the central nervous system in rhesus monkey experimental autoimmune encephalomyelitis.

Haanstra KG, Hofman SO, Lopes Estêvão DM, Blezer EL, Bauer J, Yang LL, Wyant T, Csizmadia V, 't Hart BA, Fedyk ER. Haanstra KG, et al. Among authors: yang ll. J Immunol. 2013 Mar 1;190(5):1961-73. doi: 10.4049/jimmunol.1202490. Epub 2013 Jan 30. J Immunol. 2013. PMID: 23365083

5

In vitro assessment of the effects of vedolizumab binding on peripheral blood lymphocytes.

Wyant T, Yang L, Fedyk E. Wyant T, et al. Among authors: yang l. MAbs. 2013 Nov-Dec;5(6):842-50. doi: 10.4161/mabs.26392. MAbs. 2013. PMID: 24492340 Free PMC article.

6

Comparison of the ELISA and ECL Assay for Vedolizumab Anti-drug Antibodies: Assessing the Impact on Pharmacokinetics and Safety Outcomes of the Phase 3 GEMINI Trials.

Wyant T, Yang L, Rosario M. Wyant T, et al. Among authors: yang l. AAPS J. 2020 Nov 16;23(1):3. doi: 10.1208/s12248-020-00518-0. AAPS J. 2020. PMID: 33200296 Free PMC article.

7

Vedolizumab Immunogenicity With Long-Term or Interrupted Treatment of Patients With Inflammatory Bowel Disease.

Wyant T, Yang L, Lirio RA, Rosario M. Wyant T, et al. Among authors: yang l. J Clin Pharmacol. 2021 Sep;61(9):1174-1181. doi: 10.1002/jcph.1877. Epub 2021 Jul 14. J Clin Pharmacol. 2021. PMID: 33908636 Free PMC article.

8

Pharmacokinetics and Safety of Vedolizumab Following Administration of a Single Intravenous Dose in Healthy Chinese Subjects.

Xie R, Zhao N, Jia B, Zhao X, Cui Y, Okamoto H, Yang L, Prokopienko A. Xie R, et al. Among authors: yang l. Eur J Drug Metab Pharmacokinet. 2023 Jan;48(1):35-40. doi: 10.1007/s13318-022-00804-6. Epub 2022 Nov 18. Eur J Drug Metab Pharmacokinet. 2023. PMID: 36400983 Free PMC article.

9

Measuring Serum Vedolizumab and Vedolizumab Antibodies: Comparison of Commercial Assays with the Vedolizumab Clinical Development Assay.

Vande Casteele N, Yang L, Dobler I, Agboton C, McRorie Osborn T, Suri A, Lindner D, Smithson GM. Vande Casteele N, et al. Among authors: yang l. Ther Drug Monit. 2023 Apr 1;45(2):236-244. doi: 10.1097/FTD.0000000000001068. Epub 2023 Feb 15. Ther Drug Monit. 2023. PMID: 36788448 Free PMC article.

10

Neutralizing Antibody Sample Testing and Report Harmonization.

Jani D, Gunsior M, Marsden R, Cowan KJ, Irvin SC, Hay LS, Ward B, Armstrong L, Azadeh M, Cao L, Carmean R, DelCarpini J, Dholakiya SL, Hays A, Hosback S, Hu Z, Kulagina N, Kumar S, Lai CH, Lichtfuss M, Liu HY, Liu S, Mozaffari R, Pan L, Pennucci J, Poupart ME, Saini G, Snoeck V, Storey K, Turner A, Vainshtein I, Verthelyi D, Wala I, Yang L, Yang L. Jani D, et al. Among authors: yang l. AAPS J. 2024 Jul 12;26(4):80. doi: 10.1208/s12248-024-00955-1. AAPS J. 2024. PMID: 38992280

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