de Hart GW - Search Results

1

Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.

Holder PG, Jones LC, Drake PM, Barfield RM, Bañas S, de Hart GW, Baker J, Rabuka D. Holder PG, et al. Among authors: de hart gw. J Biol Chem. 2015 Jun 19;290(25):15730-15745. doi: 10.1074/jbc.M115.652669. Epub 2015 Apr 30. J Biol Chem. 2015. PMID: 25931126 Free PMC article.

2

Site-specific chemical protein conjugation using genetically encoded aldehyde tags.

Rabuka D, Rush JS, deHart GW, Wu P, Bertozzi CR. Rabuka D, et al. Nat Protoc. 2012 May 10;7(6):1052-67. doi: 10.1038/nprot.2012.045. Nat Protoc. 2012. PMID: 22576105 Free PMC article.

3

Hydrazino-Pictet-Spengler ligation as a biocompatible method for the generation of stable protein conjugates.

Agarwal P, Kudirka R, Albers AE, Barfield RM, de Hart GW, Drake PM, Jones LC, Rabuka D. Agarwal P, et al. Among authors: de hart gw. Bioconjug Chem. 2013 Jun 19;24(6):846-51. doi: 10.1021/bc400042a. Epub 2013 Jun 3. Bioconjug Chem. 2013. PMID: 23731037

4

Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.

Drake PM, Albers AE, Baker J, Banas S, Barfield RM, Bhat AS, de Hart GW, Garofalo AW, Holder P, Jones LC, Kudirka R, McFarland J, Zmolek W, Rabuka D. Drake PM, et al. Among authors: de hart gw. Bioconjug Chem. 2014 Jul 16;25(7):1331-41. doi: 10.1021/bc500189z. Epub 2014 Jun 23. Bioconjug Chem. 2014. PMID: 24924618 Free PMC article.

5

Exploring the effects of linker composition on site-specifically modified antibody-drug conjugates.

Albers AE, Garofalo AW, Drake PM, Kudirka R, de Hart GW, Barfield RM, Baker J, Banas S, Rabuka D. Albers AE, et al. Among authors: de hart gw. Eur J Med Chem. 2014 Dec 17;88:3-9. doi: 10.1016/j.ejmech.2014.08.062. Epub 2014 Aug 23. Eur J Med Chem. 2014. PMID: 25176286

6

Generating site-specifically modified proteins via a versatile and stable nucleophilic carbon ligation.

Kudirka R, Barfield RM, McFarland J, Albers AE, de Hart GW, Drake PM, Holder PG, Banas S, Jones LC, Garofalo AW, Rabuka D. Kudirka R, et al. Among authors: de hart gw. Chem Biol. 2015 Feb 19;22(2):293-8. doi: 10.1016/j.chembiol.2014.11.019. Epub 2015 Jan 22. Chem Biol. 2015. PMID: 25619935

7

Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag.

Hudak JE, Barfield RM, de Hart GW, Grob P, Nogales E, Bertozzi CR, Rabuka D. Hudak JE, et al. Among authors: de hart gw. Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4161-5. doi: 10.1002/anie.201108130. Epub 2012 Mar 12. Angew Chem Int Ed Engl. 2012. PMID: 22407566 Free PMC article. No abstract available.

8

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay.

Cheung R, deHart GW, Jesaitis L, Zoog SJ, Melton AC. Cheung R, et al. J Vis Exp. 2018 Sep 10;(139):57777. doi: 10.3791/57777. J Vis Exp. 2018. PMID: 30247460 Free PMC article.

9

Transdominant regulation of integrin function: mechanisms of crosstalk.

Gonzalez AM, Bhattacharya R, deHart GW, Jones JC. Gonzalez AM, et al. Cell Signal. 2010 Apr;22(4):578-83. doi: 10.1016/j.cellsig.2009.10.009. Epub 2009 Oct 27. Cell Signal. 2010. PMID: 19874888 Free PMC article. Review.

10

The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel.

deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D. deHart GW, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7188-93. doi: 10.1073/pnas.0708044105. Epub 2008 May 14. Proc Natl Acad Sci U S A. 2008. PMID: 18480266 Free PMC article.

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