Direct inhibition, but indirect sensitization of pacemaker activity to sympathetic tone by the interaction of endotoxin with HCN-channels.
Ebelt H, Geißler I, Ruccius S, Otto V, Hoffmann S, Korth H, Klöckner U, Zhang Y, Li Y, Grossmann C, Rueckschloss U, Gekle M, Stieber J, Frantz S, Werdan K, Müller-Werdan U, Loppnow H.
Ebelt H, et al.
Clin Exp Pharmacol Physiol. 2015 Aug;42(8):874-80. doi: 10.1111/1440-1681.12415.
Clin Exp Pharmacol Physiol. 2015.
PMID: 25933122