Steinmetzer T - Search Results

1

Novel Furin Inhibitors with Potent Anti-infectious Activity.

Hardes K, Becker GL, Lu Y, Dahms SO, Köhler S, Beyer W, Sandvig K, Yamamoto H, Lindberg I, Walz L, von Messling V, Than ME, Garten W, Steinmetzer T. Hardes K, et al. Among authors: steinmetzer t. ChemMedChem. 2015 Jul;10(7):1218-31. doi: 10.1002/cmdc.201500103. Epub 2015 May 14. ChemMedChem. 2015. PMID: 25974265

2

Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase.

Steinmetzer T, Schweinitz A, Stürzebecher A, Dönnecke D, Uhland K, Schuster O, Steinmetzer P, Müller F, Friedrich R, Than ME, Bode W, Stürzebecher J. Steinmetzer T, et al. Among authors: steinmetzer p. J Med Chem. 2006 Jul 13;49(14):4116-26. doi: 10.1021/jm051272l. J Med Chem. 2006. PMID: 16821772

3

Highly potent and selective substrate analogue factor Xa inhibitors containing D-homophenylalanine analogues as P3 residue: part 2.

Stürzebecher A, Dönnecke D, Schweinitz A, Schuster O, Steinmetzer P, Stürzebecher U, Kotthaus J, Clement B, Stürzebecher J, Steinmetzer T. Stürzebecher A, et al. Among authors: steinmetzer t, steinmetzer p. ChemMedChem. 2007 Jul;2(7):1043-53. doi: 10.1002/cmdc.200700031. ChemMedChem. 2007. PMID: 17541992

4

MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition.

Böttcher E, Freuer C, Steinmetzer T, Klenk HD, Garten W. Böttcher E, et al. Among authors: steinmetzer t. Vaccine. 2009 Oct 23;27(45):6324-9. doi: 10.1016/j.vaccine.2009.03.029. Vaccine. 2009. PMID: 19840668

5

Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics.

Becker GL, Sielaff F, Than ME, Lindberg I, Routhier S, Day R, Lu Y, Garten W, Steinmetzer T. Becker GL, et al. Among authors: steinmetzer t. J Med Chem. 2010 Feb 11;53(3):1067-75. doi: 10.1021/jm9012455. J Med Chem. 2010. PMID: 20038105 Free PMC article.

6

Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.

Böttcher-Friebertshäuser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, Uhlendorff J, Steinmetzer T, Klenk HD, Garten W. Böttcher-Friebertshäuser E, et al. Among authors: steinmetzer t. J Virol. 2010 Jun;84(11):5605-14. doi: 10.1128/JVI.00140-10. Epub 2010 Mar 17. J Virol. 2010. PMID: 20237084 Free PMC article.

7

New furin inhibitors based on weakly basic amidinohydrazones.

Sielaff F, Than ME, Bevec D, Lindberg I, Steinmetzer T. Sielaff F, et al. Among authors: steinmetzer t. Bioorg Med Chem Lett. 2011 Jan 15;21(2):836-40. doi: 10.1016/j.bmcl.2010.11.092. Epub 2010 Nov 25. Bioorg Med Chem Lett. 2011. PMID: 21168329 Free PMC article.

8

Development of substrate analogue inhibitors for the human airway trypsin-like protease HAT.

Sielaff F, Böttcher-Friebertshäuser E, Meyer D, Saupe SM, Volk IM, Garten W, Steinmetzer T. Sielaff F, et al. Among authors: steinmetzer t. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4860-4. doi: 10.1016/j.bmcl.2011.06.033. Epub 2011 Jun 21. Bioorg Med Chem Lett. 2011. PMID: 21741839

9

New substrate analogue furin inhibitors derived from 4-amidinobenzylamide.

Becker GL, Hardes K, Steinmetzer T. Becker GL, et al. Among authors: steinmetzer t. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4695-7. doi: 10.1016/j.bmcl.2011.06.091. Epub 2011 Jun 25. Bioorg Med Chem Lett. 2011. PMID: 21757345

10

Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors.

Kuester M, Becker GL, Hardes K, Lindberg I, Steinmetzer T, Than ME. Kuester M, et al. Among authors: steinmetzer t. Biol Chem. 2011 Nov;392(11):973-81. doi: 10.1515/BC.2011.100. Epub 2011 Aug 30. Biol Chem. 2011. PMID: 21875402 Free PMC article.

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