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Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.
Mannini B, Cascella R, Zampagni M, van Waarde-Verhagen M, Meehan S, Roodveldt C, Campioni S, Boninsegna M, Penco A, Relini A, Kampinga HH, Dobson CM, Wilson MR, Cecchi C, Chiti F. Mannini B, et al. Among authors: penco a. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12479-84. doi: 10.1073/pnas.1117799109. Epub 2012 Jul 16. Proc Natl Acad Sci U S A. 2012. PMID: 22802614 Free PMC article.
Protein conformational perturbations in hereditary amyloidosis: Differential impact of single point mutations in ApoAI amyloidogenic variants.
Del Giudice R, Arciello A, Itri F, Merlino A, Monti M, Buonanno M, Penco A, Canetti D, Petruk G, Monti SM, Relini A, Pucci P, Piccoli R, Monti DM. Del Giudice R, et al. Among authors: penco a. Biochim Biophys Acta. 2016 Feb;1860(2):434-44. doi: 10.1016/j.bbagen.2015.10.019. Epub 2015 Oct 26. Biochim Biophys Acta. 2016. PMID: 26515634
Epigallocatechin-3-gallate and related phenol compounds redirect the amyloidogenic aggregation pathway of ataxin-3 towards non-toxic aggregates and prevent toxicity in neural cells and Caenorhabditis elegans animal model.
Visentin C, Pellistri F, Natalello A, Vertemara J, Bonanomi M, Gatta E, Penco A, Relini A, De Gioia L, Airoldi C, Regonesi ME, Tortora P. Visentin C, et al. Among authors: penco a. Hum Mol Genet. 2017 Sep 1;26(17):3271-3284. doi: 10.1093/hmg/ddx211. Hum Mol Genet. 2017. PMID: 28633380
28 results