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Autocrine VEGF signaling promotes proliferation of neoplastic Barrett's epithelial cells through a PLC-dependent pathway.
Zhang Q, Yu C, Peng S, Xu H, Wright E, Zhang X, Huo X, Cheng E, Pham TH, Asanuma K, Hatanpaa KJ, Rezai D, Wang DH, Sarode V, Melton S, Genta RM, Spechler SJ, Souza RF. Zhang Q, et al. Among authors: pham th. Gastroenterology. 2014 Feb;146(2):461-72.e6. doi: 10.1053/j.gastro.2013.10.011. Epub 2013 Oct 9. Gastroenterology. 2014. PMID: 24120473 Free PMC article.
In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids.
Peng S, Huo X, Rezaei D, Zhang Q, Zhang X, Yu C, Asanuma K, Cheng E, Pham TH, Wang DH, Chen M, Souza RF, Spechler SJ. Peng S, et al. Among authors: pham th. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G129-39. doi: 10.1152/ajpgi.00085.2014. Epub 2014 May 22. Am J Physiol Gastrointest Liver Physiol. 2014. PMID: 24852569 Free PMC article. Clinical Trial.
Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion.
Yu C, Huo X, Agoston AT, Zhang X, Theiss AL, Cheng E, Zhang Q, Zaika A, Pham TH, Wang DH, Lobie PE, Odze RD, Spechler SJ, Souza RF. Yu C, et al. Among authors: pham th. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 1;309(3):G146-61. doi: 10.1152/ajpgi.00462.2014. Epub 2015 Jun 4. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 26045618 Free PMC article.
Hypoxia-inducible factor-2α plays a role in mediating oesophagitis in GORD.
Huo X, Agoston AT, Dunbar KB, Cipher DJ, Zhang X, Yu C, Cheng E, Zhang Q, Pham TH, Tambar UK, Bruick RK, Wang DH, Odze RD, Spechler SJ, Souza RF. Huo X, et al. Among authors: pham th. Gut. 2017 Sep;66(9):1542-1554. doi: 10.1136/gutjnl-2016-312595. Epub 2016 Sep 30. Gut. 2017. PMID: 27694141 Free PMC article. Clinical Trial.
503 results