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A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.
Almli LM, Stevens JS, Smith AK, Kilaru V, Meng Q, Flory J, Abu-Amara D, Hammamieh R, Yang R, Mercer KB, Binder EB, Bradley B, Hamilton S, Jett M, Yehuda R, Marmar CR, Ressler KJ. Almli LM, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul;168B(5):327-36. doi: 10.1002/ajmg.b.32315. Epub 2015 May 18. Am J Med Genet B Neuropsychiatr Genet. 2015. PMID: 25988933 Free PMC article.
Sex dependent influence of a functional polymorphism in steroid 5-α-reductase type 2 (SRD5A2) on post-traumatic stress symptoms.
Gillespie CF, Almli LM, Smith AK, Bradley B, Kerley K, Crain DF, Mercer KB, Weiss T, Phifer J, Tang Y, Cubells JF, Binder EB, Conneely KN, Ressler KJ. Gillespie CF, et al. Among authors: almli lm. Am J Med Genet B Neuropsychiatr Genet. 2013 Apr;162B(3):283-292. doi: 10.1002/ajmg.b.32147. Epub 2013 Mar 15. Am J Med Genet B Neuropsychiatr Genet. 2013. PMID: 23505265 Free PMC article.
Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.
Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Andero R, et al. Sci Transl Med. 2013 Jun 5;5(188):188ra73. doi: 10.1126/scitranslmed.3005656. Sci Transl Med. 2013. PMID: 23740899 Free PMC article.
Accounting for population stratification in DNA methylation studies.
Barfield RT, Almli LM, Kilaru V, Smith AK, Mercer KB, Duncan R, Klengel T, Mehta D, Binder EB, Epstein MP, Ressler KJ, Conneely KN. Barfield RT, et al. Among authors: almli lm. Genet Epidemiol. 2014 Apr;38(3):231-41. doi: 10.1002/gepi.21789. Epub 2014 Jan 29. Genet Epidemiol. 2014. PMID: 24478250 Free PMC article.
PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus.
Stevens JS, Almli LM, Fani N, Gutman DA, Bradley B, Norrholm SD, Reiser E, Ely TD, Dhanani R, Glover EM, Jovanovic T, Ressler KJ. Stevens JS, et al. Among authors: almli lm. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3158-63. doi: 10.1073/pnas.1318954111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516127 Free PMC article.
68 results