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A genome-wide identified risk variant for PTSD is a methylation quantitative trait locus and confers decreased cortical activation to fearful faces.
Almli LM, Stevens JS, Smith AK, Kilaru V, Meng Q, Flory J, Abu-Amara D, Hammamieh R, Yang R, Mercer KB, Binder EB, Bradley B, Hamilton S, Jett M, Yehuda R, Marmar CR, Ressler KJ. Almli LM, et al. Among authors: ressler kj. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul;168B(5):327-36. doi: 10.1002/ajmg.b.32315. Epub 2015 May 18. Am J Med Genet B Neuropsychiatr Genet. 2015. PMID: 25988933 Free PMC article.
Impaired fear inhibition is a biomarker of PTSD but not depression.
Jovanovic T, Norrholm SD, Blanding NQ, Davis M, Duncan E, Bradley B, Ressler KJ. Jovanovic T, et al. Among authors: ressler kj. Depress Anxiety. 2010 Mar;27(3):244-51. doi: 10.1002/da.20663. Depress Anxiety. 2010. PMID: 20143428 Free PMC article.
529 results