Astolfi A - Search Results

1

A Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.

Astolfi A, Iraci N, Manfroni G, Barreca ML, Cecchetti V. Astolfi A, et al. ChemMedChem. 2015 Jun;10(6):957-69. doi: 10.1002/cmdc.201500030. Epub 2015 Apr 9. ChemMedChem. 2015. PMID: 26012502 Review.

2

The Pyrazolobenzothiazine Core as a New Chemotype of p38 Alpha Mitogen-Activated Protein Kinase Inhibitors.

Sabatini S, Manfroni G, Barreca ML, Bauer SM, Gargaro M, Cannalire R, Astolfi A, Brea J, Vacca C, Pirro M, Massari S, Tabarrini O, Loza MI, Fallarino F, Laufer SA, Cecchetti V. Sabatini S, et al. Among authors: astolfi a. Chem Biol Drug Des. 2015 Oct;86(4):531-45. doi: 10.1111/cbdd.12516. Epub 2015 Feb 19. Chem Biol Drug Des. 2015. PMID: 25589097

3

p38α MAPK and Type I Inhibitors: Binding Site Analysis and Use of Target Ensembles in Virtual Screening.

Astolfi A, Iraci N, Sabatini S, Barreca ML, Cecchetti V. Astolfi A, et al. Molecules. 2015 Aug 31;20(9):15842-61. doi: 10.3390/molecules200915842. Molecules. 2015. PMID: 26334265 Free PMC article.

4

Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.

Astolfi A, Felicetti T, Iraci N, Manfroni G, Massari S, Pietrella D, Tabarrini O, Kaatz GW, Barreca ML, Sabatini S, Cecchetti V. Astolfi A, et al. J Med Chem. 2017 Feb 23;60(4):1598-1604. doi: 10.1021/acs.jmedchem.6b01439. Epub 2017 Feb 8. J Med Chem. 2017. PMID: 28117588

5

Functionalized 2,1-benzothiazine 2,2-dioxides as new inhibitors of Dengue NS5 RNA-dependent RNA polymerase.

Cannalire R, Tarantino D, Astolfi A, Barreca ML, Sabatini S, Massari S, Tabarrini O, Milani M, Querat G, Mastrangelo E, Manfroni G, Cecchetti V. Cannalire R, et al. Among authors: astolfi a. Eur J Med Chem. 2018 Jan 1;143:1667-1676. doi: 10.1016/j.ejmech.2017.10.064. Epub 2017 Nov 11. Eur J Med Chem. 2018. PMID: 29137867

6

A Comprehensive Structural Overview of p38α Mitogen-Activated Protein Kinase in Complex with ATP-Site and Non-ATP-Site Binders.

Astolfi A, Manfroni G, Cecchetti V, Barreca ML. Astolfi A, et al. ChemMedChem. 2018 Jan 8;13(1):7-14. doi: 10.1002/cmdc.201700636. Epub 2017 Dec 18. ChemMedChem. 2018. PMID: 29210532 Review.

7

Modifications on C6 and C7 Positions of 3-Phenylquinolone Efflux Pump Inhibitors Led to Potent and Safe Antimycobacterial Treatment Adjuvants.

Felicetti T, Machado D, Cannalire R, Astolfi A, Massari S, Tabarrini O, Manfroni G, Barreca ML, Cecchetti V, Viveiros M, Sabatini S. Felicetti T, et al. Among authors: astolfi a. ACS Infect Dis. 2019 Jun 14;5(6):982-1000. doi: 10.1021/acsinfecdis.9b00041. Epub 2019 Apr 4. ACS Infect Dis. 2019. PMID: 30907573

8

Identification of compounds inhibiting prion replication and toxicity by removing PrP^C from the cell surface.

Biggi S, Pancher M, Stincardini C, Luotti S, Massignan T, Dalle Vedove A, Astolfi A, Gatto P, Lolli G, Barreca ML, Bonetto V, Adami V, Biasini E. Biggi S, et al. Among authors: astolfi a. J Neurochem. 2020 Jan;152(1):136-150. doi: 10.1111/jnc.14805. Epub 2019 Jul 18. J Neurochem. 2020. PMID: 31264722 Free article.

9

Deciphering the Molecular Recognition Mechanism of Multidrug Resistance Staphylococcus aureus NorA Efflux Pump Using a Supervised Molecular Dynamics Approach.

Palazzotti D, Bissaro M, Bolcato G, Astolfi A, Felicetti T, Sabatini S, Sturlese M, Cecchetti V, Barreca ML, Moro S. Palazzotti D, et al. Among authors: astolfi a. Int J Mol Sci. 2019 Aug 19;20(16):4041. doi: 10.3390/ijms20164041. Int J Mol Sci. 2019. PMID: 31430864 Free PMC article.

10

Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.

Astolfi A, Kudolo M, Brea J, Manni G, Manfroni G, Palazzotti D, Sabatini S, Cecchetti F, Felicetti T, Cannalire R, Massari S, Tabarrini O, Loza MI, Fallarino F, Cecchetti V, Laufer SA, Barreca ML. Astolfi A, et al. Eur J Med Chem. 2019 Nov 15;182:111624. doi: 10.1016/j.ejmech.2019.111624. Epub 2019 Aug 16. Eur J Med Chem. 2019. PMID: 31445234

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