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DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.
Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T. Shinjo T, et al. Among authors: fukushima t. Am J Physiol Endocrinol Metab. 2015 Aug 1;309(3):E214-23. doi: 10.1152/ajpendo.00553.2014. Epub 2015 May 26. Am J Physiol Endocrinol Metab. 2015. PMID: 26015438 Free article.
Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.
Shibata M, Hakuno F, Yamanaka D, Okajima H, Fukushima T, Hasegawa T, Ogata T, Toyoshima Y, Chida K, Kimura K, Sakoda H, Takenaka A, Asano T, Takahashi S. Shibata M, et al. Among authors: fukushima t. J Biol Chem. 2010 Jul 2;285(27):20915-25. doi: 10.1074/jbc.M110.126482. Epub 2010 Apr 29. J Biol Chem. 2010. PMID: 20430890 Free PMC article.
Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.
Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Tsuchiya Y, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: fukushima t. J Biol Chem. 2010 Oct 22;285(43):33018-33027. doi: 10.1074/jbc.M110.137836. Epub 2010 Jul 30. J Biol Chem. 2010. PMID: 20675384 Free PMC article.
Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases.
Fukushima T, Arai T, Ariga-Nedachi M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Asano T, Hakuno F, Takahashi S. Fukushima T, et al. Biochem Biophys Res Commun. 2011 Jan 21;404(3):767-73. doi: 10.1016/j.bbrc.2010.12.045. Epub 2010 Dec 17. Biochem Biophys Res Commun. 2011. PMID: 21168390
4F2hc stabilizes GLUT1 protein and increases glucose transport activity.
Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T. Ohno H, et al. Among authors: fukushima t. Am J Physiol Cell Physiol. 2011 May;300(5):C1047-54. doi: 10.1152/ajpcell.00416.2010. Epub 2011 Jan 26. Am J Physiol Cell Physiol. 2011. PMID: 21270293 Free article.
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.
Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi S, Kurihara H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: fukushima t. J Biol Chem. 2011 Jun 10;286(23):20812-22. doi: 10.1074/jbc.M110.206904. Epub 2011 Mar 17. J Biol Chem. 2011. PMID: 21454638 Free PMC article.
Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.
Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T. Iwashita M, et al. Among authors: fukushima t. Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E286-96. doi: 10.1152/ajpendo.00324.2011. Epub 2011 Nov 1. Am J Physiol Endocrinol Metab. 2012. PMID: 22045314 Free article.
Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development.
Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T. Kushiyama A, et al. Among authors: fukushima t. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):291-8. doi: 10.1161/ATVBAHA.111.234559. Epub 2011 Nov 17. Arterioscler Thromb Vasc Biol. 2012. PMID: 22095983
Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.
Yoshihara H, Fukushima T, Hakuno F, Saeki Y, Tanaka K, Ito A, Yoshida M, Iemura S, Natsume T, Asano T, Chida K, Girnita L, Takahashi S. Yoshihara H, et al. Among authors: fukushima t. Biochem Biophys Res Commun. 2012 Jun 22;423(1):122-7. doi: 10.1016/j.bbrc.2012.05.093. Epub 2012 May 23. Biochem Biophys Res Commun. 2012. PMID: 22634009
2,547 results