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Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies.
Poirot L, Philip B, Schiffer-Mannioui C, Le Clerre D, Chion-Sotinel I, Derniame S, Potrel P, Bas C, Lemaire L, Galetto R, Lebuhotel C, Eyquem J, Cheung GW, Duclert A, Gouble A, Arnould S, Peggs K, Pule M, Scharenberg AM, Smith J. Poirot L, et al. Among authors: scharenberg am. Cancer Res. 2015 Sep 15;75(18):3853-64. doi: 10.1158/0008-5472.CAN-14-3321. Epub 2015 Jul 16. Cancer Res. 2015. PMID: 26183927
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering.
Boissel S, Jarjour J, Astrakhan A, Adey A, Gouble A, Duchateau P, Shendure J, Stoddard BL, Certo MT, Baker D, Scharenberg AM. Boissel S, et al. Among authors: scharenberg am. Nucleic Acids Res. 2014 Feb;42(4):2591-601. doi: 10.1093/nar/gkt1224. Epub 2013 Nov 26. Nucleic Acids Res. 2014. PMID: 24285304 Free PMC article.
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, Scharenberg AM. Certo MT, et al. Among authors: scharenberg am. Nat Methods. 2012 Oct;9(10):973-5. doi: 10.1038/nmeth.2177. Epub 2012 Sep 2. Nat Methods. 2012. PMID: 22941364 Free PMC article.
Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells.
Hale M, Lee B, Honaker Y, Leung WH, Grier AE, Jacobs HM, Sommer K, Sahni J, Jackson SW, Scharenberg AM, Astrakhan A, Rawlings DJ. Hale M, et al. Among authors: scharenberg am. Mol Ther Methods Clin Dev. 2017 Jan 10;4:192-203. doi: 10.1016/j.omtm.2016.12.008. eCollection 2017 Mar 17. Mol Ther Methods Clin Dev. 2017. PMID: 28345004 Free PMC article.
TALEN-Mediated Gene Editing of HBG in Human Hematopoietic Stem Cells Leads to Therapeutic Fetal Hemoglobin Induction.
Lux CT, Pattabhi S, Berger M, Nourigat C, Flowers DA, Negre O, Humbert O, Yang JG, Lee C, Jacoby K, Bernstein I, Kiem HP, Scharenberg A, Rawlings DJ. Lux CT, et al. Among authors: scharenberg a. Mol Ther Methods Clin Dev. 2018 Dec 31;12:175-183. doi: 10.1016/j.omtm.2018.12.008. eCollection 2019 Mar 15. Mol Ther Methods Clin Dev. 2018. PMID: 30705922 Free PMC article.
128 results