Höfgen N - Search Results

1

Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography.

Schröder S, Wenzel B, Deuther-Conrad W, Teodoro R, Egerland U, Kranz M, Scheunemann M, Höfgen N, Steinbach J, Brust P. Schröder S, et al. Among authors: hofgen n. Molecules. 2015 May 26;20(6):9591-615. doi: 10.3390/molecules20069591. Molecules. 2015. PMID: 26016549 Free PMC article.

2

Investigation of an ¹⁸F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A.

Schröder S, Wenzel B, Deuther-Conrad W, Teodoro R, Kranz M, Scheunemann M, Egerland U, Höfgen N, Briel D, Steinbach J, Brust P. Schröder S, et al. Among authors: hofgen n. Molecules. 2018 Mar 2;23(3):556. doi: 10.3390/molecules23030556. Molecules. 2018. PMID: 29498659 Free PMC article.

3

Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.

Höfgen N, Stange H, Schindler R, Lankau HJ, Grunwald C, Langen B, Egerland U, Tremmel P, Pangalos MN, Marquis KL, Hage T, Harrison BL, Malamas MS, Brandon NJ, Kronbach T. Höfgen N, et al. J Med Chem. 2010 Jun 10;53(11):4399-411. doi: 10.1021/jm1002793. J Med Chem. 2010. PMID: 20450197

4

Fluorine-containing 6,7-dialkoxybiaryl-based inhibitors for phosphodiesterase 10 A: synthesis and in vitro evaluation of inhibitory potency, selectivity, and metabolism.

Schwan G, Barbar Asskar G, Höfgen N, Kubicova L, Funke U, Egerland U, Zahn M, Nieber K, Scheunemann M, Sträter N, Brust P, Briel D. Schwan G, et al. Among authors: hofgen n. ChemMedChem. 2014 Jul;9(7):1476-87. doi: 10.1002/cmdc.201300522. Epub 2014 Apr 11. ChemMedChem. 2014. PMID: 24729456

5

5-(4-Hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-2,3,6,7-tetrahydro-1,4-thiazepines as compounds with high affinity at the benzodiazepine binding site on GABA(A) receptors.

Grunwald C, Kronbach C, Egerland U, Schindler R, Dieckmann R, Heinecke K, Höfgen N, Unverferth K. Grunwald C, et al. Among authors: hofgen n. Pharmazie. 2011 Feb;66(2):98-104. doi: 10.1002/chin.201125210. Pharmazie. 2011. PMID: 21434570

6

Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

Grunwald C, Rundfeldt C, Lankau HJ, Arnold T, Höfgen N, Dost R, Egerland U, Hofmann HJ, Unverferth K. Grunwald C, et al. Among authors: hofgen n. J Med Chem. 2006 Mar 23;49(6):1855-66. doi: 10.1021/jm0509400. J Med Chem. 2006. PMID: 16539371

7

1,5-Disubstituted indazol-3-ols with anti-inflammatory activity.

Schindler R, Fleischhauer I, Höfgen N, Sauer W, Egerland U, Poppe H, Heer S, Szelenyi I, Kutscher B, Engel J. Schindler R, et al. Among authors: hofgen n. Arch Pharm (Weinheim). 1998 Jan;331(1):13-21. doi: 10.1002/(SICI)1521-4184(199801)331:1<13::AID-ARDP13>3.0.CO;2-M. Arch Pharm (Weinheim). 1998. PMID: 9507697

8

The phosphodiesterase 4 inhibitor AWD 12-281 is active in a new guinea-pig model of allergic skin inflammation predictive of human skin penetration and suppresses both Th1 and Th2 cytokines in mice.

Hoppmann J, Bäumer W, Galetzka C, Höfgen N, Kietzmann M, Rundfeldt C. Hoppmann J, et al. Among authors: hofgen n. J Pharm Pharmacol. 2005 Dec;57(12):1609-17. doi: 10.1211/jpp.57.12.0011. J Pharm Pharmacol. 2005. PMID: 16354405

9

Synthesis, anticonvulsant activity, and structure-activity relationships of sodium channel blocking 3-aminopyrroles.

Unverferth K, Engel J, Höfgen N, Rostock A, Günther R, Lankau HJ, Menzer M, Rolfs A, Liebscher J, Müller B, Hofmann HJ. Unverferth K, et al. Among authors: hofgen n. J Med Chem. 1998 Jan 1;41(1):63-73. doi: 10.1021/jm970327j. J Med Chem. 1998. PMID: 9438023

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