Tchasovnikarova IA - Search Results

1

GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.

Tchasovnikarova IA, Timms RT, Matheson NJ, Wals K, Antrobus R, Göttgens B, Dougan G, Dawson MA, Lehner PJ. Tchasovnikarova IA, et al. Science. 2015 Jun 26;348(6242):1481-1485. doi: 10.1126/science.aaa7227. Epub 2015 May 28. Science. 2015. PMID: 26022416 Free PMC article.

2

Position-effect variegation revisited: HUSHing up heterochromatin in human cells.

Timms RT, Tchasovnikarova IA, Lehner PJ. Timms RT, et al. Among authors: tchasovnikarova ia. Bioessays. 2016 Apr;38(4):333-43. doi: 10.1002/bies.201500184. Epub 2016 Feb 8. Bioessays. 2016. PMID: 26853531 Review.

3

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ. Timms RT, et al. Among authors: tchasovnikarova ia. Cell Rep. 2016 Oct 11;17(3):653-659. doi: 10.1016/j.celrep.2016.09.050. Cell Rep. 2016. PMID: 27732843 Free PMC article.

4

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ. Tchasovnikarova IA, et al. Nat Genet. 2017 Jul;49(7):1035-1044. doi: 10.1038/ng.3878. Epub 2017 Jun 5. Nat Genet. 2017. PMID: 28581500 Free PMC article.

5

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

Timms RT, Duncan LM, Tchasovnikarova IA, Antrobus R, Smith DL, Dougan G, Weekes MP, Lehner PJ. Timms RT, et al. Among authors: tchasovnikarova ia. PLoS Pathog. 2013;9(11):e1003772. doi: 10.1371/journal.ppat.1003772. Epub 2013 Nov 21. PLoS Pathog. 2013. PMID: 24278019 Free PMC article.

6

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC, Antrobus R, Dougan G, Ellgaard L, Lehner PJ. Timms RT, et al. Among authors: tchasovnikarova ia. Nat Commun. 2016 Jun 10;7:11786. doi: 10.1038/ncomms11786. Nat Commun. 2016. PMID: 27283361 Free PMC article.

7

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.

Douse CH, Bloor S, Liu Y, Shamin M, Tchasovnikarova IA, Timms RT, Lehner PJ, Modis Y. Douse CH, et al. Among authors: tchasovnikarova ia. Nat Commun. 2018 Feb 13;9(1):651. doi: 10.1038/s41467-018-03045-x. Nat Commun. 2018. PMID: 29440755 Free PMC article.

8

The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.

Robbez-Masson L, Tie CHC, Conde L, Tunbak H, Husovsky C, Tchasovnikarova IA, Timms RT, Herrero J, Lehner PJ, Rowe HM. Robbez-Masson L, et al. Among authors: tchasovnikarova ia. Genome Res. 2018 Jun;28(6):836-845. doi: 10.1101/gr.228171.117. Epub 2018 May 4. Genome Res. 2018. PMID: 29728366 Free PMC article.

9

Periphilin self-association underpins epigenetic silencing by the HUSH complex.

Prigozhin DM, Douse CH, Farleigh LE, Albecka A, Tchasovnikarova IA, Timms RT, Oda SI, Adolf F, Freund SMV, Maslen S, Lehner PJ, Modis Y. Prigozhin DM, et al. Among authors: tchasovnikarova ia. Nucleic Acids Res. 2020 Oct 9;48(18):10313-10328. doi: 10.1093/nar/gkaa785. Nucleic Acids Res. 2020. PMID: 32976585 Free PMC article.

10

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.

Douse CH, Tchasovnikarova IA, Timms RT, Protasio AV, Seczynska M, Prigozhin DM, Albecka A, Wagstaff J, Williamson JC, Freund SMV, Lehner PJ, Modis Y. Douse CH, et al. Among authors: tchasovnikarova ia. Nat Commun. 2020 Oct 2;11(1):4940. doi: 10.1038/s41467-020-18761-6. Nat Commun. 2020. PMID: 33009411 Free PMC article.

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