Herpers B - Search Results

1

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.

Herpers B, Wink S, Fredriksson L, Di Z, Hendriks G, Vrieling H, de Bont H, van de Water B. Herpers B, et al. Arch Toxicol. 2016 May;90(5):1163-79. doi: 10.1007/s00204-015-1536-3. Epub 2015 May 31. Arch Toxicol. 2016. PMID: 26026609 Free PMC article.

2

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells.

Benedetti G, Fredriksson L, Herpers B, Meerman J, van de Water B, de Graauw M. Benedetti G, et al. Among authors: herpers b. Biochem Pharmacol. 2013 Jan 15;85(2):274-86. doi: 10.1016/j.bcp.2012.10.012. Epub 2012 Oct 24. Biochem Pharmacol. 2013. PMID: 23103562

3

Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening.

Di Z, Herpers B, Fredriksson L, Yan K, van de Water B, Verbeek FJ, Meerman JH. Di Z, et al. Among authors: herpers b. PLoS One. 2012;7(12):e52337. doi: 10.1371/journal.pone.0052337. Epub 2012 Dec 27. PLoS One. 2012. PMID: 23300644 Free PMC article.

4

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Wink S, Hiemstra S, Huppelschoten S, Danen E, Niemeijer M, Hendriks G, Vrieling H, Herpers B, van de Water B. Wink S, et al. Among authors: herpers b. Chem Res Toxicol. 2014 Mar 17;27(3):338-55. doi: 10.1021/tx4004038. Epub 2014 Feb 5. Chem Res Toxicol. 2014. PMID: 24450961 Review.

5

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.

Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, van de Water B, Price LS. Ramaiahgari SC, et al. Among authors: herpers b. Arch Toxicol. 2014 May;88(5):1083-95. doi: 10.1007/s00204-014-1215-9. Epub 2014 Mar 6. Arch Toxicol. 2014. PMID: 24599296

6

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Fredriksson L, et al. Among authors: herpers b. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20. Toxicol Sci. 2014. PMID: 24752500

7

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.

Wink S, Hiemstra S, Herpers B, van de Water B. Wink S, et al. Among authors: herpers b. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29. Arch Toxicol. 2017. PMID: 27358234 Free PMC article.

8

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis.

Fredriksson L, Herpers B, Benedetti G, Matadin Q, Puigvert JC, de Bont H, Dragovic S, Vermeulen NP, Commandeur JN, Danen E, de Graauw M, van de Water B. Fredriksson L, et al. Among authors: herpers b. Hepatology. 2011 Jun;53(6):2027-41. doi: 10.1002/hep.24314. Hepatology. 2011. PMID: 21433042

9

The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch.

Benedetti G, Fokkelman M, Yan K, Fredriksson L, Herpers B, Meerman J, van de Water B, de Graauw M. Benedetti G, et al. Among authors: herpers b. Mol Pharmacol. 2013 Jul;84(1):128-38. doi: 10.1124/mol.112.084053. Epub 2013 Apr 26. Mol Pharmacol. 2013. PMID: 23625948

10

A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.

Benedetti G, Ramaiahgaris S, Herpers B, van de Water B, Price LS, de Graauw M. Benedetti G, et al. Among authors: herpers b. Toxicol In Vitro. 2013 Dec;27(8):2264-72. doi: 10.1016/j.tiv.2013.09.004. Epub 2013 Sep 13. Toxicol In Vitro. 2013. PMID: 24041534

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