de Bont H - Search Results

1

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.

Herpers B, Wink S, Fredriksson L, Di Z, Hendriks G, Vrieling H, de Bont H, van de Water B. Herpers B, et al. Among authors: de bont h. Arch Toxicol. 2016 May;90(5):1163-79. doi: 10.1007/s00204-015-1536-3. Epub 2015 May 31. Arch Toxicol. 2016. PMID: 26026609 Free PMC article.

2

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Fredriksson L, et al. Among authors: de bont h. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20. Toxicol Sci. 2014. PMID: 24752500

3

High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability.

Hiemstra S, Ramaiahgari SC, Wink S, Callegaro G, Coonen M, Meerman J, Jennen D, van den Nieuwendijk K, Dankers A, Snoeys J, de Bont H, Price L, van de Water B. Hiemstra S, et al. Among authors: de bont h. Arch Toxicol. 2019 Oct;93(10):2895-2911. doi: 10.1007/s00204-019-02552-0. Epub 2019 Aug 27. Arch Toxicol. 2019. PMID: 31552476

4

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis.

Fredriksson L, Herpers B, Benedetti G, Matadin Q, Puigvert JC, de Bont H, Dragovic S, Vermeulen NP, Commandeur JN, Danen E, de Graauw M, van de Water B. Fredriksson L, et al. Among authors: de graauw m, de bont h. Hepatology. 2011 Jun;53(6):2027-41. doi: 10.1002/hep.24314. Hepatology. 2011. PMID: 21433042

5

FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells.

He J, Wink S, de Bont H, Le Dévédec S, Zhang Y, van de Water B. He J, et al. Among authors: de bont h. Biochem Pharmacol. 2019 Nov;169:113640. doi: 10.1016/j.bcp.2019.113640. Epub 2019 Sep 16. Biochem Pharmacol. 2019. PMID: 31536726 Free article.

6

Functional screening with a live cell imaging-based random cell migration assay.

van Roosmalen W, Le Dévédec SE, Zovko S, de Bont H, van de Water B. van Roosmalen W, et al. Among authors: de bont h. Methods Mol Biol. 2011;769:435-48. doi: 10.1007/978-1-61779-207-6_29. Methods Mol Biol. 2011. PMID: 21748693

7

Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes.

Koedoot E, Fokkelman M, Rogkoti VM, Smid M, van de Sandt I, de Bont H, Pont C, Klip JE, Wink S, Timmermans MA, Wiemer EAC, Stoilov P, Foekens JA, Le Dévédec SE, Martens JWM, van de Water B. Koedoot E, et al. Among authors: de bont h. Nat Commun. 2019 Jul 5;10(1):2983. doi: 10.1038/s41467-019-11020-3. Nat Commun. 2019. PMID: 31278301 Free PMC article.

8

Two-photon intravital multicolor imaging combined with inducible gene expression to distinguish metastatic behavior of breast cancer cells in vivo.

Le Dévédec SE, Lalai R, Pont C, de Bont H, van de Water B. Le Dévédec SE, et al. Among authors: de bont h. Mol Imaging Biol. 2011 Feb;13(1):67-77. doi: 10.1007/s11307-010-0307-z. Mol Imaging Biol. 2011. PMID: 20396956 Free PMC article.

9

High-throughput live cell imaging of apoptosis.

Puigvert JC, de Bont H, van de Water B, Danen EH. Puigvert JC, et al. Among authors: de bont h. Curr Protoc Cell Biol. 2010 Jun;Chapter 18:Unit 18.10.1-13. doi: 10.1002/0471143030.cb1810s47. Curr Protoc Cell Biol. 2010. PMID: 20521231

10

Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes.

Zhang Y, Moerkens M, Ramaiahgari S, de Bont H, Price L, Meerman J, van de Water B. Zhang Y, et al. Among authors: de bont h. Breast Cancer Res. 2011 May 19;13(3):R52. doi: 10.1186/bcr2883. Breast Cancer Res. 2011. PMID: 21595894 Free PMC article.

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