Zhu J - Search Results

1

Discovery of benzylidene derivatives as potent Syk inhibitors: synthesis, SAR analysis, and biological evaluation.

Zhang L, Liu W, Mao F, Zhu J, Dong G, Jiang H, Sheng C, Miao L, Huang L, Li J. Zhang L, et al. Among authors: zhu j. Arch Pharm (Weinheim). 2015 Jul;348(7):463-74. doi: 10.1002/ardp.201500096. Epub 2015 Jun 1. Arch Pharm (Weinheim). 2015. PMID: 26032727

2

Discovery of novel Syk/PDGFR-α/c-Kit inhibitors as multi-targeting drugs to treat rheumatoid arthritis.

Li X, Huang Y, Cheng J, Zhang L, Mao F, Zhu J, Sheng C, Li J. Li X, et al. Among authors: zhu j. Bioorg Med Chem. 2018 Aug 15;26(15):4375-4381. doi: 10.1016/j.bmc.2018.06.029. Epub 2018 Jun 22. Bioorg Med Chem. 2018. PMID: 30078608

3

Synthesis, structure-activity relationship, and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors.

Wu D, Jin F, Lu W, Zhu J, Li C, Wang W, Tang Y, Jiang H, Huang J, Liu G, Li J. Wu D, et al. Among authors: zhu j. Chem Biol Drug Des. 2012 Jun;79(6):897-906. doi: 10.1111/j.1747-0285.2012.01365.x. Epub 2012 Mar 21. Chem Biol Drug Des. 2012. PMID: 22381062

4

Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists.

Huang H, Yu Y, Gao Z, Zhang Y, Li C, Xu X, Jin H, Yan W, Ma R, Zhu J, Shen X, Jiang H, Chen L, Li J. Huang H, et al. Among authors: zhu j. J Med Chem. 2012 Aug 23;55(16):7037-53. doi: 10.1021/jm3002718. Epub 2012 Aug 10. J Med Chem. 2012. PMID: 22862148

5

Discovery of new imidazole derivatives containing the 2,4-dienone motif with broad-spectrum antifungal and antibacterial activity.

Liu C, Shi C, Mao F, Xu Y, Liu J, Wei B, Zhu J, Xiang M, Li J. Liu C, et al. Among authors: zhu j. Molecules. 2014 Sep 29;19(10):15653-72. doi: 10.3390/molecules191015653. Molecules. 2014. PMID: 25268720 Free PMC article.

6

Development of second-generation small-molecule RhoA inhibitors with enhanced water solubility, tissue potency, and significant in vivo efficacy.

Ma S, Deng J, Li B, Li X, Yan Z, Zhu J, Chen G, Wang Z, Jiang H, Miao L, Li J. Ma S, et al. Among authors: zhu j. ChemMedChem. 2015 Jan;10(1):193-206. doi: 10.1002/cmdc.201402386. Epub 2014 Nov 5. ChemMedChem. 2015. PMID: 25377276

7

Design, Synthesis, and Biological Evaluation of Novel Nonsteroidal Farnesoid X Receptor (FXR) Antagonists: Molecular Basis of FXR Antagonism.

Huang H, Si P, Wang L, Xu Y, Xu X, Zhu J, Jiang H, Li W, Chen L, Li J. Huang H, et al. Among authors: zhu j. ChemMedChem. 2015 Jul;10(7):1184-99. doi: 10.1002/cmdc.201500136. Epub 2015 May 15. ChemMedChem. 2015. PMID: 25982493

8

Discovery of Novel Small Molecule Anti-HCV Agents via the CypA Inhibitory Mechanism Using O-Acylation-Directed Lead Optimization.

Yan W, Qing J, Mei H, Mao F, Huang J, Zhu J, Jiang H, Liu L, Zhang L, Li J. Yan W, et al. Among authors: zhu j. Molecules. 2015 Jun 4;20(6):10342-59. doi: 10.3390/molecules200610342. Molecules. 2015. PMID: 26053489 Free PMC article.

9

Identification, synthesis and pharmacological evaluation of novel anti-EV71 agents via cyclophilin A inhibition.

Yan W, Qing J, Mei H, Nong J, Huang J, Zhu J, Jiang H, Liu L, Zhang L, Li J. Yan W, et al. Among authors: zhu j. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5682-6. doi: 10.1016/j.bmcl.2015.11.002. Epub 2015 Nov 2. Bioorg Med Chem Lett. 2015. PMID: 26564266

10

Discovery of Potent Benzofuran-Derived Diapophytoene Desaturase (CrtN) Inhibitors with Enhanced Oral Bioavailability for the Treatment of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.

Wang Y, Chen F, Di H, Xu Y, Xiao Q, Wang X, Wei H, Lu Y, Zhang L, Zhu J, Sheng C, Lan L, Li J. Wang Y, et al. Among authors: zhu j. J Med Chem. 2016 Apr 14;59(7):3215-30. doi: 10.1021/acs.jmedchem.5b01984. Epub 2016 Apr 5. J Med Chem. 2016. PMID: 26999509

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