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A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.
Kinzel L, Ernst A, Orth M, Albrecht V, Hennel R, Brix N, Frey B, Gaipl US, Zuchtriegel G, Reichel CA, Blutke A, Schilling D, Multhoff G, Li M, Niyazi M, Friedl AA, Winssinger N, Belka C, Lauber K. Kinzel L, et al. Among authors: ernst a. Oncotarget. 2016 Jul 12;7(28):43199-43219. doi: 10.18632/oncotarget.9774. Oncotarget. 2016. PMID: 27259245 Free PMC article.
Current concepts in clinical radiation oncology.
Orth M, Lauber K, Niyazi M, Friedl AA, Li M, Maihöfer C, Schüttrumpf L, Ernst A, Niemöller OM, Belka C. Orth M, et al. Among authors: ernst a. Radiat Environ Biophys. 2014 Mar;53(1):1-29. doi: 10.1007/s00411-013-0497-2. Epub 2013 Oct 20. Radiat Environ Biophys. 2014. PMID: 24141602 Free PMC article. Review.
Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells.
Krombach J, Hennel R, Brix N, Orth M, Schoetz U, Ernst A, Schuster J, Zuchtriegel G, Reichel CA, Bierschenk S, Sperandio M, Vogl T, Unkel S, Belka C, Lauber K. Krombach J, et al. Among authors: ernst a. Oncoimmunology. 2018 Nov 2;8(1):e1523097. doi: 10.1080/2162402X.2018.1523097. eCollection 2019. Oncoimmunology. 2018. PMID: 30546963 Free PMC article.
Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function.
Wunderlich R, Ernst A, Rödel F, Fietkau R, Ott O, Lauber K, Frey B, Gaipl US. Wunderlich R, et al. Among authors: ernst a. Clin Exp Immunol. 2015 Jan;179(1):50-61. doi: 10.1111/cei.12344. Clin Exp Immunol. 2015. PMID: 24730395 Free PMC article.
1,275 results