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Page 1
Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair.
Harnicek D, Kampmann E, Lauber K, Hennel R, Cardoso Martins AS, Guo Y, Belka C, Mörtl S, Gallmeier E, Kanaar R, Mansmann U, Hucl T, Lindner LH, Hiddemann W, Issels RD. Harnicek D, et al. Among authors: hennel r. Int J Cancer. 2016 Jul 15;139(2):467-79. doi: 10.1002/ijc.30070. Epub 2016 Mar 25. Int J Cancer. 2016. PMID: 26933761
A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.
Kinzel L, Ernst A, Orth M, Albrecht V, Hennel R, Brix N, Frey B, Gaipl US, Zuchtriegel G, Reichel CA, Blutke A, Schilling D, Multhoff G, Li M, Niyazi M, Friedl AA, Winssinger N, Belka C, Lauber K. Kinzel L, et al. Among authors: hennel r. Oncotarget. 2016 Jul 12;7(28):43199-43219. doi: 10.18632/oncotarget.9774. Oncotarget. 2016. PMID: 27259245 Free PMC article.
Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.
Ernst A, Hennel R, Krombach J, Kapfhammer H, Brix N, Zuchtriegel G, Uhl B, Reichel CA, Frey B, Gaipl US, Winssinger N, Shirasawa S, Sasazuki T, Sperandio M, Belka C, Lauber K. Ernst A, et al. Among authors: hennel r. Front Oncol. 2020 Aug 27;10:1668. doi: 10.3389/fonc.2020.01668. eCollection 2020. Front Oncol. 2020. PMID: 32984042 Free PMC article.
Early senescence and production of senescence-associated cytokines are major determinants of radioresistance in head-and-neck squamous cell carcinoma.
Schoetz U, Klein D, Hess J, Shnayien S, Spoerl S, Orth M, Mutlu S, Hennel R, Sieber A, Ganswindt U, Luka B, Thomsen AR, Unger K, Jendrossek V, Zitzelsberger H, Blüthgen N, Belka C, Unkel S, Klinger B, Lauber K. Schoetz U, et al. Among authors: hennel r. Cell Death Dis. 2021 Dec 15;12(12):1162. doi: 10.1038/s41419-021-04454-5. Cell Death Dis. 2021. PMID: 34911941 Free PMC article.
Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells.
Krombach J, Hennel R, Brix N, Orth M, Schoetz U, Ernst A, Schuster J, Zuchtriegel G, Reichel CA, Bierschenk S, Sperandio M, Vogl T, Unkel S, Belka C, Lauber K. Krombach J, et al. Among authors: hennel r. Oncoimmunology. 2018 Nov 2;8(1):e1523097. doi: 10.1080/2162402X.2018.1523097. eCollection 2019. Oncoimmunology. 2018. PMID: 30546963 Free PMC article.
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