Shimokawa Y - Search Results

1

Pharmacokinetics and Metabolism of Delamanid, a Novel Anti-Tuberculosis Drug, in Animals and Humans: Importance of Albumin Metabolism In Vivo.

Sasahara K, Shimokawa Y, Hirao Y, Koyama N, Kitano K, Shibata M, Umehara K. Sasahara K, et al. Among authors: shimokawa y. Drug Metab Dispos. 2015 Aug;43(8):1267-76. doi: 10.1124/dmd.115.064527. Epub 2015 Jun 8. Drug Metab Dispos. 2015. PMID: 26055620

2

Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro.

Shimokawa Y, Sasahara K, Yoda N, Mizuno K, Umehara K. Shimokawa Y, et al. Biol Pharm Bull. 2014;37(11):1727-35. doi: 10.1248/bpb.b14-00311. Biol Pharm Bull. 2014. PMID: 25366478 Free article.

3

Metabolic Mechanism of Delamanid, a New Anti-Tuberculosis Drug, in Human Plasma.

Shimokawa Y, Sasahara K, Koyama N, Kitano K, Shibata M, Yoda N, Umehara K. Shimokawa Y, et al. Drug Metab Dispos. 2015 Aug;43(8):1277-83. doi: 10.1124/dmd.115.064550. Epub 2015 Jun 8. Drug Metab Dispos. 2015. PMID: 26055621

4

Absorption, distribution and excretion of the anti-tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis.

Shibata M, Shimokawa Y, Sasahara K, Yoda N, Sasabe H, Suzuki M, Umehara K. Shibata M, et al. Among authors: shimokawa y. Biopharm Drug Dispos. 2017 May;38(4):301-312. doi: 10.1002/bdd.2064. Epub 2017 Mar 8. Biopharm Drug Dispos. 2017. PMID: 28092695

5

Inhibition of human drug metabolizing cytochrome P450 by buprenorphine.

Umehara K, Shimokawa Y, Miyamoto G. Umehara K, et al. Among authors: shimokawa y. Biol Pharm Bull. 2002 May;25(5):682-5. doi: 10.1248/bpb.25.682. Biol Pharm Bull. 2002. PMID: 12033517 Free article.

6

Effect of probucol on cytochrome P450 activities in human liver microsomes.

Umehara K, Shimokawa Y, Miyamoto G. Umehara K, et al. Among authors: shimokawa y. Biol Pharm Bull. 2002 Aug;25(8):1112-4. doi: 10.1248/bpb.25.1112. Biol Pharm Bull. 2002. PMID: 12186421 Free article.

7

Effect of gamma-oryzanol on cytochrome P450 activities in human liver microsomes.

Umehara K, Shimokawa Y, Miyamoto G. Umehara K, et al. Among authors: shimokawa y. Biol Pharm Bull. 2004 Jul;27(7):1151-3. doi: 10.1248/bpb.27.1151. Biol Pharm Bull. 2004. PMID: 15256760 Free article.

8

Inhibitory Potential of Twenty Five Anti-tuberculosis Drugs on CYP Activities in Human Liver Microsomes.

Shimokawa Y, Yoda N, Kondo S, Yamamura Y, Takiguchi Y, Umehara K. Shimokawa Y, et al. Biol Pharm Bull. 2015;38(9):1425-9. doi: 10.1248/bpb.b15-00313. Epub 2015 Jun 20. Biol Pharm Bull. 2015. PMID: 26094899 Free article.

9

Antitubercular Agent Delamanid and Metabolites as Substrates and Inhibitors of ABC and Solute Carrier Transporters.

Sasabe H, Shimokawa Y, Shibata M, Hashizume K, Hamasako Y, Ohzone Y, Kashiyama E, Umehara K. Sasabe H, et al. Among authors: shimokawa y. Antimicrob Agents Chemother. 2016 May 23;60(6):3497-508. doi: 10.1128/AAC.03049-15. Print 2016 Jun. Antimicrob Agents Chemother. 2016. PMID: 27021329 Free PMC article.

10

Oxidative one-carbon cleavage of the octyl side chain of olanexidine, a novel antimicrobial agent, in dog liver microsomes.

Umehara K, Shimokawa Y, Koga T, Ohtani T, Miyamoto G. Umehara K, et al. Among authors: shimokawa y. Xenobiotica. 2004 Jan;34(1):61-71. doi: 10.1080/00498250310001646335. Xenobiotica. 2004. PMID: 14742137

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