Op de Beeck A - Search Results

1

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells.

Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL. Marroqui L, et al. Among authors: op de beeck a. Elife. 2015 Jun 10;4:e06990. doi: 10.7554/eLife.06990. Elife. 2015. PMID: 26061776 Free PMC article.

2

Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.

Colli ML, Nogueira TC, Allagnat F, Cunha DA, Gurzov EN, Cardozo AK, Roivainen M, Op de Beeck A, Eizirik DL. Colli ML, et al. Among authors: op de beeck a. PLoS Pathog. 2011 Sep;7(9):e1002267. doi: 10.1371/journal.ppat.1002267. Epub 2011 Sep 22. PLoS Pathog. 2011. PMID: 21977009 Free PMC article.

3

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells.

Marroqui L, Dos Santos RS, Fløyel T, Grieco FA, Santin I, Op de Beeck A, Marselli L, Marchetti P, Pociot F, Eizirik DL. Marroqui L, et al. Among authors: op de beeck a. Diabetes. 2015 Nov;64(11):3808-17. doi: 10.2337/db15-0362. Epub 2015 Aug 3. Diabetes. 2015. PMID: 26239055

4

Viral infections in type 1 diabetes mellitus--why the β cells?

Op de Beeck A, Eizirik DL. Op de Beeck A, et al. Nat Rev Endocrinol. 2016 May;12(5):263-273. doi: 10.1038/nrendo.2016.30. Epub 2016 Mar 29. Nat Rev Endocrinol. 2016. PMID: 27020257 Free PMC article. Review.

5

Coxsackievirus and Type 1 Diabetes Mellitus: The Wolf's Footprints.

Eizirik DL, Op de Beeck A. Eizirik DL, et al. Among authors: op de beeck a. Trends Endocrinol Metab. 2018 Mar;29(3):137-139. doi: 10.1016/j.tem.2017.12.002. Epub 2018 Jan 8. Trends Endocrinol Metab. 2018. PMID: 29326001

6

Coxsackievirus B Tailors the Unfolded Protein Response to Favour Viral Amplification in Pancreatic β Cells.

Colli ML, Paula FM, Marselli L, Marchetti P, Roivainen M, Eizirik DL, Op de Beeck A. Colli ML, et al. Among authors: op de beeck a. J Innate Immun. 2019;11(4):375-390. doi: 10.1159/000496034. Epub 2019 Feb 20. J Innate Immun. 2019. PMID: 30799417 Free PMC article.

7

Interferon-α mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes.

Marroqui L, Dos Santos RS, Op de Beeck A, Coomans de Brachène A, Marselli L, Marchetti P, Eizirik DL. Marroqui L, et al. Among authors: op de beeck a. Diabetologia. 2017 Apr;60(4):656-667. doi: 10.1007/s00125-016-4201-3. Epub 2017 Jan 6. Diabetologia. 2017. PMID: 28062922

8

PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction.

Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, Marselli L, Krogvold L, Dahl-Jorgensen K, Marchetti P, Morgan NG, Richardson SJ, Eizirik DL. Colli ML, et al. Among authors: op de beeck a. EBioMedicine. 2018 Oct;36:367-375. doi: 10.1016/j.ebiom.2018.09.040. Epub 2018 Sep 27. EBioMedicine. 2018. PMID: 30269996 Free PMC article.

9

Preclinical evaluation of tyrosine kinase 2 inhibitors for human beta-cell protection in type 1 diabetes.

Coomans de Brachène A, Castela A, Op de Beeck A, Mirmira RG, Marselli L, Marchetti P, Masse C, Miao W, Leit S, Evans-Molina C, Eizirik DL. Coomans de Brachène A, et al. Among authors: op de beeck a. Diabetes Obes Metab. 2020 Oct;22(10):1827-1836. doi: 10.1111/dom.14104. Epub 2020 Jul 5. Diabetes Obes Metab. 2020. PMID: 32476252 Free PMC article.

10

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.

Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL. Szymczak F, et al. Among authors: op de beeck a. Sci Adv. 2022 Sep 16;8(37):eabn5732. doi: 10.1126/sciadv.abn5732. Epub 2022 Sep 14. Sci Adv. 2022. PMID: 36103539 Free PMC article.

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