Ohara H - Search Results

1

Cardiohemodynamic and electrophysiological effects of a selective EP4 receptor agonist ONO--AE1--329 in the halothane-anesthetized dogs.

Nomura H, Nakamura Y, Cao X, Honda A, Katagi J, Ohara H, Izumi-Nakaseko H, Satoh Y, Ando K, Sugiyama A. Nomura H, et al. Among authors: ohara h. Eur J Pharmacol. 2015 Aug 15;761:217-25. doi: 10.1016/j.ejphar.2015.06.012. Epub 2015 Jun 11. Eur J Pharmacol. 2015. PMID: 26073024

2

Effects of selective IKr channel blockade by E-4031 on ventricular electro-mechanical relationship in the halothane-anesthetized dogs.

Izumi-Nakaseko H, Nakamura Y, Cao X, Ohara H, Yamazaki Y, Ueda N, Ando K, Sugiyama A. Izumi-Nakaseko H, et al. Among authors: ohara h. Eur J Pharmacol. 2014 Oct 5;740:263-70. doi: 10.1016/j.ejphar.2014.06.064. Epub 2014 Jul 17. Eur J Pharmacol. 2014. PMID: 25038475

3

Analysis of Onset Mechanisms of a Sphingosine 1-Phosphate Receptor Modulator Fingolimod-Induced Atrioventricular Conduction Block and QT-Interval Prolongation.

Yagi Y, Nakamura Y, Kitahara K, Harada T, Kato K, Ninomiya T, Cao X, Ohara H, Izumi-Nakaseko H, Suzuki K, Ando K, Sugiyama A. Yagi Y, et al. Among authors: ohara h. Toxicol Appl Pharmacol. 2014 Nov 15;281(1):39-47. doi: 10.1016/j.taap.2014.09.006. Epub 2014 Sep 16. Toxicol Appl Pharmacol. 2014. PMID: 25223691

4

Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence from In Vivo Canine Models.

Watanabe Y, Nakamura Y, Cao X, Ohara H, Yamazaki Y, Murayama N, Sugiyama Y, Izumi-Nakaseko H, Ando K, Yamazaki H, Sugiyama A. Watanabe Y, et al. Among authors: ohara h. Basic Clin Pharmacol Toxicol. 2015 Jun;116(6):468-75. doi: 10.1111/bcpt.12343. Epub 2014 Nov 22. Basic Clin Pharmacol Toxicol. 2015. PMID: 25370785 Free article.

5

Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations.

Yamazaki-Hashimoto Y, Nakamura Y, Ohara H, Cao X, Kitahara K, Izumi-Nakaseko H, Ando K, Yamazaki H, Ikeda T, Yamazaki J, Sugiyama A. Yamazaki-Hashimoto Y, et al. Among authors: ohara h. J Toxicol Sci. 2015 Feb;40(1):33-42. doi: 10.2131/jts.40.33. J Toxicol Sci. 2015. PMID: 25560394 Free article.

6

Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K(+) Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model.

Katagi J, Nakamura Y, Cao X, Ohara H, Honda A, Izumi-Nakaseko H, Ando K, Sugiyama A. Katagi J, et al. Among authors: ohara h. Cardiovasc Toxicol. 2016 Apr;16(2):138-46. doi: 10.1007/s12012-015-9322-2. Cardiovasc Toxicol. 2016. PMID: 25822712

7

Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs.

Wada T, Nakamura Y, Cao X, Ohara H, Izumi-Nakaseko H, Ando K, Nakazato Y, Sugiyama A. Wada T, et al. Among authors: ohara h. J Toxicol Sci. 2016 Feb;41(1):115-22. doi: 10.2131/jts.41.115. J Toxicol Sci. 2016. PMID: 26763398 Free article.

8

Effects of a prostagrandin EP4-receptor agonist ONO-AE1-329 on the left ventricular pressure-volume relationship in the halothane-anesthetized dogs.

Honda A, Nakamura Y, Ohara H, Cao X, Nomura H, Katagi J, Wada T, Izumi-Nakaseko H, Ando K, Sugiyama A. Honda A, et al. Among authors: ohara h. Eur J Pharmacol. 2016 Mar 15;775:130-7. doi: 10.1016/j.ejphar.2016.02.029. Epub 2016 Feb 9. Eur J Pharmacol. 2016. PMID: 26872985

9

Azithromycin Can Prolong QT Interval and Suppress Ventricular Contraction, but Will Not Induce Torsade de Pointes.

Ohara H, Nakamura Y, Watanabe Y, Cao X, Yamazaki Y, Izumi-Nakaseko H, Ando K, Yamazaki H, Yamazaki J, Ikeda T, Sugiyama A. Ohara H, et al. Cardiovasc Toxicol. 2015 Jul;15(3):232-40. doi: 10.1007/s12012-014-9289-4. Cardiovasc Toxicol. 2015. PMID: 25367413

10

Feasible induction of coronary artery vasospasm occurred during cardiac catheterization in a microminipig.

Matsukura S, Nakamura Y, Ohara H, Cao X, Wada T, Izumi-Nakaseko H, Ando K, Akasaka Y, Sugiyama A. Matsukura S, et al. Among authors: ohara h. J Vet Med Sci. 2016 Jun 1;78(5):873-6. doi: 10.1292/jvms.15-0426. Epub 2016 Jan 23. J Vet Med Sci. 2016. PMID: 26806564 Free PMC article.

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