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AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia.
Van de Velde S, Van Bergen T, Sijnave D, Hollanders K, Castermans K, Defert O, Leysen D, Vandewalle E, Moons L, Stalmans I. Van de Velde S, et al. Among authors: castermans k. Invest Ophthalmol Vis Sci. 2014 Feb 18;55(2):1006-16. doi: 10.1167/iovs.13-13157. Invest Ophthalmol Vis Sci. 2014. PMID: 24474276 Free article.
Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors.
Boland S, Bourin A, Alen J, Geraets J, Schroeders P, Castermans K, Kindt N, Boumans N, Panitti L, Fransen S, Vanormelingen J, Stassen JM, Leysen D, Defert O. Boland S, et al. Among authors: castermans k. J Med Chem. 2015 May 28;58(10):4309-24. doi: 10.1021/acs.jmedchem.5b00308. Epub 2015 May 6. J Med Chem. 2015. PMID: 25898023
Design, synthesis and biological characterization of selective LIMK inhibitors.
Boland S, Bourin A, Alen J, Geraets J, Schroeders P, Castermans K, Kindt N, Boumans N, Panitti L, Vanormelingen J, Fransen S, Van de Velde S, Defert O. Boland S, et al. Among authors: castermans k. Bioorg Med Chem Lett. 2015 Sep 15;25(18):4005-10. doi: 10.1016/j.bmcl.2015.07.009. Epub 2015 Jul 10. Bioorg Med Chem Lett. 2015. PMID: 26233434
Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor.
Holvoet T, Devriese S, Castermans K, Boland S, Leysen D, Vandewynckel YP, Devisscher L, Van den Bossche L, Van Welden S, Dullaers M, Vandenbroucke RE, De Rycke R, Geboes K, Bourin A, Defert O, Hindryckx P, De Vos M, Laukens D. Holvoet T, et al. Among authors: castermans k. Gastroenterology. 2017 Oct;153(4):1054-1067. doi: 10.1053/j.gastro.2017.06.013. Epub 2017 Jun 19. Gastroenterology. 2017. PMID: 28642198
30 results