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A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity.
Garcia-Perez J, Staropoli I, Azoulay S, Heinrich JT, Cascajero A, Colin P, Lortat-Jacob H, Arenzana-Seisdedos F, Alcami J, Kellenberger E, Lagane B. Garcia-Perez J, et al. Among authors: kellenberger e. Retrovirology. 2015 Jun 18;12:50. doi: 10.1186/s12977-015-0177-1. Retrovirology. 2015. PMID: 26081316 Free PMC article.
Small neutralizing molecules to inhibit actions of the chemokine CXCL12.
Hachet-Haas M, Balabanian K, Rohmer F, Pons F, Franchet C, Lecat S, Chow KY, Dagher R, Gizzi P, Didier B, Lagane B, Kellenberger E, Bonnet D, Baleux F, Haiech J, Parmentier M, Frossard N, Arenzana-Seisdedos F, Hibert M, Galzi JL. Hachet-Haas M, et al. Among authors: kellenberger e. J Biol Chem. 2008 Aug 22;283(34):23189-99. doi: 10.1074/jbc.M803947200. Epub 2008 Jun 13. J Biol Chem. 2008. PMID: 18556651 Free article.
Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).
Garcia-Perez J, Rueda P, Alcami J, Rognan D, Arenzana-Seisdedos F, Lagane B, Kellenberger E. Garcia-Perez J, et al. Among authors: kellenberger e. J Biol Chem. 2011 Sep 23;286(38):33409-21. doi: 10.1074/jbc.M111.279596. Epub 2011 Jul 20. J Biol Chem. 2011. PMID: 21775441 Free PMC article.
Modeling the allosteric modulation of CCR5 function by Maraviroc.
Lagane B, Garcia-Perez J, Kellenberger E. Lagane B, et al. Among authors: kellenberger e. Drug Discov Today Technol. 2013 Summer;10(2):e297-305. doi: 10.1016/j.ddtec.2012.07.011. Drug Discov Today Technol. 2013. PMID: 24050281 Review.
CCR5 adopts three homodimeric conformations that control cell surface delivery.
Jin J, Momboisse F, Boncompain G, Koensgen F, Zhou Z, Cordeiro N, Arenzana-Seisdedos F, Perez F, Lagane B, Kellenberger E, Brelot A. Jin J, et al. Among authors: kellenberger e. Sci Signal. 2018 May 8;11(529):eaal2869. doi: 10.1126/scisignal.aal2869. Sci Signal. 2018. PMID: 29739880
sc-PDB: a 3D-database of ligandable binding sites--10 years on.
Desaphy J, Bret G, Rognan D, Kellenberger E. Desaphy J, et al. Among authors: kellenberger e. Nucleic Acids Res. 2015 Jan;43(Database issue):D399-404. doi: 10.1093/nar/gku928. Epub 2014 Oct 9. Nucleic Acids Res. 2015. PMID: 25300483 Free PMC article.
213 results