Holder JR - Search Results

1

Sustained inhibition of the NaV1.7 sodium channel by engineered dimers of the domain II binding peptide GpTx-1.

Murray JK, Biswas K, Holder JR, Zou A, Ligutti J, Liu D, Poppe L, Andrews KL, Lin FF, Meng SY, Moyer BD, McDonough SI, Miranda LP. Murray JK, et al. Among authors: holder jr. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4866-4871. doi: 10.1016/j.bmcl.2015.06.033. Epub 2015 Jun 16. Bioorg Med Chem Lett. 2015. PMID: 26112439

2

Engineering Antibody Reactivity for Efficient Derivatization to Generate Na_V1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates.

Biswas K, Nixey TE, Murray JK, Falsey JR, Yin L, Liu H, Gingras J, Hall BE, Herberich B, Holder JR, Li H, Ligutti J, Lin MJ, Liu D, Soriano BD, Soto M, Tran L, Tegley CM, Zou A, Gunasekaran K, Moyer BD, Doherty L, Miranda LP. Biswas K, et al. Among authors: holder jr. ACS Chem Biol. 2017 Sep 15;12(9):2427-2435. doi: 10.1021/acschembio.7b00542. Epub 2017 Aug 28. ACS Chem Biol. 2017. PMID: 28800217

3

Half-life extension of peptidic APJ agonists by N-terminal lipid conjugation.

Reed AB, Lanman BA, Holder JR, Yang BH, Ma J, Humphreys SC, Wang Z, Chan JCY, Miranda LP, Swaminath G, Allen JG. Reed AB, et al. Among authors: holder jr. Bioorg Med Chem Lett. 2020 Nov 1;30(21):127499. doi: 10.1016/j.bmcl.2020.127499. Epub 2020 Aug 26. Bioorg Med Chem Lett. 2020. PMID: 32858124

4

Identification of potent, selective, and metabolically stable peptide antagonists to the calcitonin gene-related peptide (CGRP) receptor.

Miranda LP, Holder JR, Shi L, Bennett B, Aral J, Gegg CV, Wright M, Walker K, Doellgast G, Rogers R, Li H, Valladares V, Salyers K, Johnson E, Wild K. Miranda LP, et al. Among authors: holder jr. J Med Chem. 2008 Dec 25;51(24):7889-97. doi: 10.1021/jm8009298. J Med Chem. 2008. PMID: 19053766

5

Direct quantitative analysis of a 20 kDa PEGylated human calcitonin gene peptide antagonist in cynomolgus monkey serum using in-source CID and UPLC-MS/MS.

Li H, Rose MJ, Holder JR, Wright M, Miranda LP, James CA. Li H, et al. Among authors: holder jr. J Am Soc Mass Spectrom. 2011 Sep;22(9):1660-7. doi: 10.1007/s13361-011-0180-2. Epub 2011 Jun 23. J Am Soc Mass Spectrom. 2011. PMID: 21953269

6

Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics.

Miranda LP, Shi L, Holder JR, Wright M, Gegg CV, Johnson E, Wild K, Stenkilsson M, Doellgast G, Manning BH, Salyers K. Miranda LP, et al. Among authors: holder jr. Biopolymers. 2013 Jul;100(4):422-30. doi: 10.1002/bip.22270. Biopolymers. 2013. PMID: 23868210

7

Identification and Optimization of a Minor Allele-Specific siRNA to Prevent PNPLA3 I148M-Driven Nonalcoholic Fatty Liver Disease.

Murray JK, Long J, Liu L, Singh S, Pruitt D, Ollmann M, Swearingen E, Hardy M, Homann O, Wu B, Holder JR, Sham K, Herberich B, Lo MC, Dou H, Shkumatov A, Florio M, Rulifson IC. Murray JK, et al. Among authors: holder jr. Nucleic Acid Ther. 2021 Oct;31(5):324-340. doi: 10.1089/nat.2021.0026. Epub 2021 Jul 23. Nucleic Acid Ther. 2021. PMID: 34297902

8

Incorporation of a bioactive reverse-turn heterocycle into a peptide template using solid-phase synthesis to probe melanocortin receptor selectivity and ligand conformations by 2D 1H NMR.

Singh A, Wilczynski A, Holder JR, Witek RM, Dirain ML, Xiang Z, Edison AS, Haskell-Luevano C. Singh A, et al. Among authors: holder jr. J Med Chem. 2011 Mar 10;54(5):1379-90. doi: 10.1021/jm101425m. Epub 2011 Feb 9. J Med Chem. 2011. PMID: 21306168 Free PMC article.

9

Development and validation of a method for the determination of a therapeutic peptide with affinity for the human B1 receptor in human plasma using HPLC-MS/MS.

Wilson SF, Li H, Rose MJ, Xiao J, Holder JR, James CA. Wilson SF, et al. Among authors: holder jr. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Mar 15;878(9-10):749-57. doi: 10.1016/j.jchromb.2010.01.018. Epub 2010 Jan 25. J Chromatogr B Analyt Technol Biomed Life Sci. 2010. PMID: 20167545

10

Design and pharmacology of peptoids and peptide-peptoid hybrids based on the melanocortin agonists core tetrapeptide sequence.

Holder JR, Bauzo RM, Xiang Z, Scott J, Haskell-Luevano C. Holder JR, et al. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4505-9. doi: 10.1016/j.bmcl.2003.08.078. Bioorg Med Chem Lett. 2003. PMID: 14643357

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