Hope AG - Search Results

1

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM. Kazlauskaite A, et al. Among authors: hope ag. EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25. EMBO Rep. 2015. PMID: 26116755 Free PMC article.

2

Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs).

Heap RE, Hope AG, Pearson LA, Reyskens KMSE, McElroy SP, Hastie CJ, Porter DW, Arthur JSC, Gray DW, Trost M. Heap RE, et al. Among authors: hope ag. SLAS Discov. 2017 Dec;22(10):1193-1202. doi: 10.1177/2472555217717473. Epub 2017 Jul 10. SLAS Discov. 2017. PMID: 28692323 Free PMC article.

3

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Major M17-Leucyl Aminopeptidase from Trypanosoma cruzi Using RapidFire Mass Spectrometry.

Izquierdo M, Lin D, O'Neill S, Zoltner M, Webster L, Hope A, Gray DW, Field MC, González-Bacerio J. Izquierdo M, et al. SLAS Discov. 2020 Oct;25(9):1064-1071. doi: 10.1177/2472555220923367. Epub 2020 May 13. SLAS Discov. 2020. PMID: 32400260 Free article.

4

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem.

Martins da Silva SJ, Brown SG, Sutton K, King LV, Ruso H, Gray DW, Wyatt PG, Kelly MC, Barratt CLR, Hope AG. Martins da Silva SJ, et al. Among authors: hope ag. Hum Reprod. 2017 May 1;32(5):974-984. doi: 10.1093/humrep/dex055. Hum Reprod. 2017. PMID: 28333338 Free PMC article.

5

Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function.

McBrinn RC, Fraser J, Hope AG, Gray DW, Barratt CLR, Martins da Silva SJ, Brown SG. McBrinn RC, et al. Among authors: hope ag. Br J Pharmacol. 2019 Dec;176(23):4521-4536. doi: 10.1111/bph.14814. Epub 2019 Dec 11. Br J Pharmacol. 2019. PMID: 31368510 Free PMC article.

6

A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA.

Moynié L, Hope AG, Finzel K, Schmidberger J, Leckie SM, Schneider G, Burkart MD, Smith AD, Gray DW, Naismith JH. Moynié L, et al. Among authors: hope ag. J Mol Biol. 2016 Jan 16;428(1):108-120. doi: 10.1016/j.jmb.2015.10.027. Epub 2015 Nov 10. J Mol Biol. 2016. PMID: 26562505 Free PMC article.

7

Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.

Armstrong LA, Lange SM, Dee Cesare V, Matthews SP, Nirujogi RS, Cole I, Hope A, Cunningham F, Toth R, Mukherjee R, Bojkova D, Gruber F, Gray D, Wyatt PG, Cinatl J, Dikic I, Davies P, Kulathu Y. Armstrong LA, et al. PLoS One. 2021 Jul 16;16(7):e0253364. doi: 10.1371/journal.pone.0253364. eCollection 2021. PLoS One. 2021. PMID: 34270554 Free PMC article.

8

Discovery of an allosteric inhibitor binding site in 3-Oxo-acyl-ACP reductase from Pseudomonas aeruginosa.

Cukier CD, Hope AG, Elamin AA, Moynie L, Schnell R, Schach S, Kneuper H, Singh M, Naismith JH, Lindqvist Y, Gray DW, Schneider G. Cukier CD, et al. Among authors: hope ag. ACS Chem Biol. 2013 Nov 15;8(11):2518-27. doi: 10.1021/cb4005063. Epub 2013 Sep 23. ACS Chem Biol. 2013. PMID: 24015914 Free PMC article.

9

The interaction of trichloroethanol with murine recombinant 5-HT3 receptors.

Downie DL, Hope AG, Belelli D, Lambert JJ, Peters JA, Bentley KR, Steward LJ, Chen CY, Barnes NM. Downie DL, et al. Among authors: hope ag. Br J Pharmacol. 1995 Apr;114(8):1641-51. doi: 10.1111/j.1476-5381.1995.tb14952.x. Br J Pharmacol. 1995. PMID: 7541281 Free PMC article.

10

Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells.

Hope AG, Peters JA, Brown AM, Lambert JJ, Blackburn TP. Hope AG, et al. Br J Pharmacol. 1996 Jul;118(5):1237-45. doi: 10.1111/j.1476-5381.1996.tb15529.x. Br J Pharmacol. 1996. PMID: 8818349 Free PMC article.

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