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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.
Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM. Kazlauskaite A, et al. Among authors: van aalten dm. EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25. EMBO Rep. 2015. PMID: 26116755 Free PMC article.
Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.
Komander D, Kular GS, Schüttelkopf AW, Deak M, Prakash KR, Bain J, Elliott M, Garrido-Franco M, Kozikowski AP, Alessi DR, van Aalten DM. Komander D, et al. Among authors: van aalten dm. Structure. 2004 Feb;12(2):215-26. doi: 10.1016/j.str.2004.01.005. Structure. 2004. PMID: 14962382 Free article.
PDK1, the master regulator of AGC kinase signal transduction.
Mora A, Komander D, van Aalten DM, Alessi DR. Mora A, et al. Among authors: van aalten dm. Semin Cell Dev Biol. 2004 Apr;15(2):161-70. doi: 10.1016/j.semcdb.2003.12.022. Semin Cell Dev Biol. 2004. PMID: 15209375 Review.
210 results