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Page 1
Intensive pharmacological immunosuppression allows for repetitive liver gene transfer with recombinant adenovirus in nonhuman primates.
Fontanellas A, Hervás-Stubbs S, Mauleón I, Dubrot J, Mancheño U, Collantes M, Sampedro A, Unzu C, Alfaro C, Palazón A, Smerdou C, Benito A, Prieto J, Peñuelas I, Melero I. Fontanellas A, et al. Among authors: mancheno u. Mol Ther. 2010 Apr;18(4):754-65. doi: 10.1038/mt.2009.312. Epub 2010 Jan 19. Mol Ther. 2010. PMID: 20087317 Free PMC article.
Short-Term Local Expression of a PD-L1 Blocking Antibody from a Self-Replicating RNA Vector Induces Potent Antitumor Responses.
Ballesteros-Briones MC, Martisova E, Casales E, Silva-Pilipich N, Buñuales M, Galindo J, Mancheño U, Gorraiz M, Lasarte JJ, Kochan G, Escors D, Sanchez-Paulete AR, Melero I, Prieto J, Hernandez-Alcoceba R, Hervas-Stubbs S, Smerdou C. Ballesteros-Briones MC, et al. Among authors: mancheno u. Mol Ther. 2019 Nov 6;27(11):1892-1905. doi: 10.1016/j.ymthe.2019.09.016. Epub 2019 Sep 16. Mol Ther. 2019. PMID: 31563534 Free PMC article.
Oxaliplatin in combination with liver-specific expression of interleukin 12 reduces the immunosuppressive microenvironment of tumours and eradicates metastatic colorectal cancer in mice.
Gonzalez-Aparicio M, Alzuguren P, Mauleon I, Medina-Echeverz J, Hervas-Stubbs S, Mancheno U, Berraondo P, Crettaz J, Gonzalez-Aseguinolaza G, Prieto J, Hernandez-Alcoceba R. Gonzalez-Aparicio M, et al. Among authors: mancheno u. Gut. 2011 Mar;60(3):341-9. doi: 10.1136/gut.2010.211722. Epub 2010 Sep 20. Gut. 2011. PMID: 20855451 Free article.
CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.
Hervas-Stubbs S, Mancheño U, Riezu-Boj JI, Larraga A, Ochoa MC, Alignani D, Alfaro C, Morales-Kastresana A, Gonzalez I, Larrea E, Pircher H, Le Bon A, Lopez-Picazo JM, Martín-Algarra S, Prieto J, Melero I. Hervas-Stubbs S, et al. Among authors: mancheno u. J Immunol. 2012 Oct 1;189(7):3299-310. doi: 10.4049/jimmunol.1102495. Epub 2012 Aug 27. J Immunol. 2012. PMID: 22925929
Strict requirement for vector-induced type I interferon in efficacious antitumor responses to virally encoded IL12.
Melero I, Quetglas JI, Reboredo M, Dubrot J, Rodriguez-Madoz JR, Mancheño U, Casales E, Riezu-Boj JI, Ruiz-Guillen M, Ochoa MC, Sanmamed MF, Thieblemont N, Smerdou C, Hervas-Stubbs S. Melero I, et al. Among authors: mancheno u. Cancer Res. 2015 Feb 1;75(3):497-507. doi: 10.1158/0008-5472.CAN-13-3356. Epub 2014 Dec 19. Cancer Res. 2015. PMID: 25527611
Adenovirus-Mediated Inducible Expression of a PD-L1 Blocking Antibody in Combination with Macrophage Depletion Improves Survival in a Mouse Model of Peritoneal Carcinomatosis.
Buñuales M, Ballesteros-Briones MC, Gonzalez-Aparicio M, Hervas-Stubbs S, Martisova E, Mancheño U, Ricobaraza A, Lumbreras S, Smerdou C, Hernandez-Alcoceba R. Buñuales M, et al. Among authors: mancheno u. Int J Mol Sci. 2021 Apr 17;22(8):4176. doi: 10.3390/ijms22084176. Int J Mol Sci. 2021. PMID: 33920699 Free PMC article.
FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma.
Conde E, Casares N, Mancheño U, Elizalde E, Vercher E, Capozzi R, Santamaria E, Rodriguez-Madoz JR, Prosper F, Lasarte JJ, Lozano T, Hervas-Stubbs S. Conde E, et al. Among authors: mancheno u. Mol Ther. 2023 Jan 4;31(1):48-65. doi: 10.1016/j.ymthe.2022.08.017. Epub 2022 Aug 31. Mol Ther. 2023. PMID: 36045586 Free PMC article.
19 results