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Dynamic population pharmacokinetic-pharmacodynamic modelling and simulation supports similar efficacy in glycosylated haemoglobin response with once or twice-daily dosing of canagliflozin.
de Winter W, Dunne A, de Trixhe XW, Devineni D, Hsu CH, Pinheiro J, Polidori D. de Winter W, et al. Among authors: pinheiro j. Br J Clin Pharmacol. 2017 May;83(5):1072-1081. doi: 10.1111/bcp.13180. Epub 2017 Jan 31. Br J Clin Pharmacol. 2017. PMID: 28138980 Free PMC article. Clinical Trial.
Innovative approaches for designing and analyzing adaptive dose-ranging trials.
Bornkamp B, Bretz F, Dmitrienko A, Enas G, Gaydos B, Hsu CH, König F, Krams M, Liu Q, Neuenschwander B, Parke T, Pinheiro J, Roy A, Sax R, Shen F. Bornkamp B, et al. Among authors: pinheiro j. J Biopharm Stat. 2007;17(6):965-95. doi: 10.1080/10543400701643848. J Biopharm Stat. 2007. PMID: 18027208
Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop.
Romero K, Sinha V, Allerheiligen S, Danhof M, Pinheiro J, Kruhlak N, Wang Y, Wang SJ, Sauer JM, Marier JF, Corrigan B, Rogers J, Lambers Heerspink HJ, Gumbo T, Vis P, Watkins P, Morrison T, Gillespie W, Gordon MF, Stephenson D, Hanna D, Pfister M, Lalonde R, Colatsky T. Romero K, et al. Among authors: pinheiro j. J Pharmacokinet Pharmacodyn. 2014 Dec;41(6):545-52. doi: 10.1007/s10928-014-9390-0. Epub 2014 Oct 7. J Pharmacokinet Pharmacodyn. 2014. PMID: 25288257
743 results