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Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions.
Qiu Y, Chen J, Liao H, Zhang Y, Wang H, Li S, Luo Y, Fang D, Li G, Zhou B, Shen L, Chen CY, Huang D, Cai J, Cao K, Jiang L, Zeng G, Chen ZW. Qiu Y, et al. Among authors: shen l. PLoS Pathog. 2012;8(11):e1002984. doi: 10.1371/journal.ppat.1002984. Epub 2012 Nov 8. PLoS Pathog. 2012. PMID: 23144609 Free PMC article. Clinical Trial.
Immunization of Vγ2Vδ2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates.
Shen L, Frencher J, Huang D, Wang W, Yang E, Chen CY, Zhang Z, Wang R, Qaqish A, Larsen MH, Shen H, Porcelli SA, Jacobs WR Jr, Chen ZW. Shen L, et al. Among authors: shen h. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6371-6378. doi: 10.1073/pnas.1811380116. Epub 2019 Mar 8. Proc Natl Acad Sci U S A. 2019. PMID: 30850538 Free PMC article.
Immune distribution and localization of phosphoantigen-specific Vgamma2Vdelta2 T cells in lymphoid and nonlymphoid tissues in Mycobacterium tuberculosis infection.
Huang D, Shen Y, Qiu L, Chen CY, Shen L, Estep J, Hunt R, Vasconcelos D, Du G, Aye P, Lackner AA, Larsen MH, Jacobs WR Jr, Haynes BF, Letvin NL, Chen ZW. Huang D, et al. Among authors: shen y, shen l. Infect Immun. 2008 Jan;76(1):426-36. doi: 10.1128/IAI.01008-07. Epub 2007 Oct 8. Infect Immun. 2008. PMID: 17923514 Free PMC article.
Severe tuberculosis induces unbalanced up-regulation of gene networks and overexpression of IL-22, MIP-1alpha, CCL27, IP-10, CCR4, CCR5, CXCR3, PD1, PDL2, IL-3, IFN-beta, TIM1, and TLR2 but low antigen-specific cellular responses.
Qiu L, Huang D, Chen CY, Wang R, Shen L, Shen Y, Hunt R, Estep J, Haynes BF, Jacobs WR Jr, Letvin N, Du G, Chen ZW. Qiu L, et al. Among authors: shen y, shen l. J Infect Dis. 2008 Nov 15;198(10):1514-9. doi: 10.1086/592448. J Infect Dis. 2008. PMID: 18811584 Free PMC article.
A critical role for CD8 T cells in a nonhuman primate model of tuberculosis.
Chen CY, Huang D, Wang RC, Shen L, Zeng G, Yao S, Shen Y, Halliday L, Fortman J, McAllister M, Estep J, Hunt R, Vasconcelos D, Du G, Porcelli SA, Larsen MH, Jacobs WR Jr, Haynes BF, Letvin NL, Chen ZW. Chen CY, et al. Among authors: shen y, shen l. PLoS Pathog. 2009 Apr;5(4):e1000392. doi: 10.1371/journal.ppat.1000392. Epub 2009 Apr 17. PLoS Pathog. 2009. PMID: 19381260 Free PMC article.
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