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Screening of quinoline, 1,3-benzoxazine, and 1,3-oxazine-based small molecules against isolated methionyl-tRNA synthetase and A549 and HCT116 cancer cells including an in silico binding mode analysis.
Bharathkumar H, Mohan CD, Rangappa S, Kang T, Keerthy HK, Fuchs JE, Kwon NH, Bender A, Kim S, Basappa, Rangappa KS. Bharathkumar H, et al. Among authors: fuchs je. Org Biomol Chem. 2015 Sep 28;13(36):9381-7. doi: 10.1039/c5ob00791g. Epub 2015 Jul 10. Org Biomol Chem. 2015. PMID: 26159576
Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo.
Mohan CD, Bharathkumar H, Bulusu KC, Pandey V, Rangappa S, Fuchs JE, Shanmugam MK, Dai X, Li F, Deivasigamani A, Hui KM, Kumar AP, Lobie PE, Bender A, Basappa, Sethi G, Rangappa KS. Mohan CD, et al. Among authors: fuchs je. J Biol Chem. 2014 Dec 5;289(49):34296-307. doi: 10.1074/jbc.M114.601104. Epub 2014 Oct 15. J Biol Chem. 2014. PMID: 25320076 Free PMC article.
Synthesis and characterization of novel oxazines and demonstration that they specifically target cyclooxygenase 2.
Srinivas V, Mohan CD, Baburajeev CP, Rangappa S, Jagadish S, Fuchs JE, Sukhorukov AY, Chandra, Mason DJ, Sharath Kumar KS, Madegowda M, Bender A, Basappa, Rangappa KS. Srinivas V, et al. Among authors: fuchs je. Bioorg Med Chem Lett. 2015 Aug 1;25(15):2931-6. doi: 10.1016/j.bmcl.2015.05.047. Epub 2015 May 27. Bioorg Med Chem Lett. 2015. PMID: 26048794
Novel Adamantanyl-Based Thiadiazolyl Pyrazoles Targeting EGFR in Triple-Negative Breast Cancer.
Sebastian A, Pandey V, Mohan CD, Chia YT, Rangappa S, Mathai J, Baburajeev CP, Paricharak S, Mervin LH, Bulusu KC, Fuchs JE, Bender A, Yamada S, Basappa, Lobie PE, Rangappa KS. Sebastian A, et al. Among authors: fuchs je. ACS Omega. 2016 Dec 31;1(6):1412-1424. doi: 10.1021/acsomega.6b00251. Epub 2016 Dec 28. ACS Omega. 2016. PMID: 30023509 Free PMC article.
Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation.
Pandey V, Wang B, Mohan CD, Raquib AR, Rangappa S, Srinivasa V, Fuchs JE, Girish KS, Zhu T, Bender A, Ma L, Yin Z, Basappa, Rangappa KS, Lobie PE. Pandey V, et al. Among authors: fuchs je. Proc Natl Acad Sci U S A. 2018 Oct 30;115(44):E10505-E10514. doi: 10.1073/pnas.1804897115. Epub 2018 Oct 11. Proc Natl Acad Sci U S A. 2018. PMID: 30309962 Free PMC article.
103 results