Abi-Gerges N - Search Results

1

A New Perspective in the Field of Cardiac Safety Testing through the Comprehensive In Vitro Proarrhythmia Assay Paradigm.

Fermini B, Hancox JC, Abi-Gerges N, Bridgland-Taylor M, Chaudhary KW, Colatsky T, Correll K, Crumb W, Damiano B, Erdemli G, Gintant G, Imredy J, Koerner J, Kramer J, Levesque P, Li Z, Lindqvist A, Obejero-Paz CA, Rampe D, Sawada K, Strauss DG, Vandenberg JI. Fermini B, et al. J Biomol Screen. 2016 Jan;21(1):1-11. doi: 10.1177/1087057115594589. Epub 2015 Jul 13. J Biomol Screen. 2016. PMID: 26170255 Review.

2

Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT.

Bridgland-Taylor MH, Hargreaves AC, Easter A, Orme A, Henthorn DC, Ding M, Davis AM, Small BG, Heapy CG, Abi-Gerges N, Persson F, Jacobson I, Sullivan M, Albertson N, Hammond TG, Sullivan E, Valentin JP, Pollard CE. Bridgland-Taylor MH, et al. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):189-99. doi: 10.1016/j.vascn.2006.02.003. Epub 2006 Mar 6. J Pharmacol Toxicol Methods. 2006. PMID: 16563806

3

Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes.

Hardy ME, Pollard CE, Small BG, Bridgland-Taylor M, Woods AJ, Valentin JP, Abi-Gerges N. Hardy ME, et al. J Pharmacol Toxicol Methods. 2009 Jul-Aug;60(1):94-106. doi: 10.1016/j.vascn.2009.03.005. Epub 2009 May 4. J Pharmacol Toxicol Methods. 2009. PMID: 19414070

4

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk.

Pollard CE, Abi Gerges N, Bridgland-Taylor MH, Easter A, Hammond TG, Valentin JP. Pollard CE, et al. Br J Pharmacol. 2010 Jan;159(1):12-21. doi: 10.1111/j.1476-5381.2009.00207.x. Br J Pharmacol. 2010. PMID: 20141516 Free PMC article. Review.

5

Predicting changes in cardiac myocyte contractility during early drug discovery with in vitro assays.

Morton MJ, Armstrong D, Abi Gerges N, Bridgland-Taylor M, Pollard CE, Bowes J, Valentin JP. Morton MJ, et al. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):87-94. doi: 10.1016/j.taap.2014.06.005. Epub 2014 Jun 18. Toxicol Appl Pharmacol. 2014. PMID: 24952337

6

Prediction of Thorough QT study results using action potential simulations based on ion channel screens.

Mirams GR, Davies MR, Brough SJ, Bridgland-Taylor MH, Cui Y, Gavaghan DJ, Abi-Gerges N. Mirams GR, et al. J Pharmacol Toxicol Methods. 2014 Nov-Dec;70(3):246-54. doi: 10.1016/j.vascn.2014.07.002. Epub 2014 Jul 31. J Pharmacol Toxicol Methods. 2014. PMID: 25087753 Free PMC article.

7

Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel.

Mannikko R, Bridgland-Taylor MH, Pye H, Swallow S, Abi-Gerges N, Morton MJ, Pollard CE. Mannikko R, et al. Br J Pharmacol. 2015 Jun;172(12):3112-25. doi: 10.1111/bph.13115. Epub 2015 Apr 10. Br J Pharmacol. 2015. PMID: 25684549 Free PMC article.

8

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Hill AP, Perry MD, Abi-Gerges N, Couderc JP, Fermini B, Hancox JC, Knollmann BC, Mirams GR, Skinner J, Zareba W, Vandenberg JI. Hill AP, et al. J Physiol. 2016 Dec 1;594(23):6893-6908. doi: 10.1113/JP272015. Epub 2016 Jun 9. J Physiol. 2016. PMID: 27060987 Free PMC article.

9

Human ex-vivo action potential model for pro-arrhythmia risk assessment.

Page G, Ratchada P, Miron Y, Steiner G, Ghetti A, Miller PE, Reynolds JA, Wang K, Greiter-Wilke A, Polonchuk L, Traebert M, Gintant GA, Abi-Gerges N. Page G, et al. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:183-95. doi: 10.1016/j.vascn.2016.05.016. Epub 2016 May 25. J Pharmacol Toxicol Methods. 2016. PMID: 27235787 Free PMC article.

10

Assessment of extracellular field potential and Ca²⁺ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes.

Abi-Gerges N, Pointon A, Oldman KL, Brown MR, Pilling MA, Sefton CE, Garside H, Pollard CE. Abi-Gerges N, et al. J Pharmacol Toxicol Methods. 2017 Jan-Feb;83:1-15. doi: 10.1016/j.vascn.2016.09.001. Epub 2016 Sep 10. J Pharmacol Toxicol Methods. 2017. PMID: 27622857

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