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A novel anti-B7-H3 chimeric antigen receptor from a single-chain antibody library for immunotherapy of solid cancers.
Birley K, Leboreiro-Babe C, Rota EM, Buschhaus M, Gavriil A, Vitali A, Alonso-Ferrero M, Hopwood L, Parienti L, Ferry G, Flutter B, Himoudi N, Chester K, Anderson J. Birley K, et al. Among authors: rota em. Mol Ther Oncolytics. 2022 Aug 25;26:429-443. doi: 10.1016/j.omto.2022.08.008. eCollection 2022 Sep 15. Mol Ther Oncolytics. 2022. PMID: 36159778 Free PMC article.
Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma.
Fowler D, Barisa M, Southern A, Nattress C, Hawkins E, Vassalou E, Kanouta A, Counsell J, Rota E, Vlckova P, Draper B, De Mooij T, Farkas A, Brezovjakova H, Baker AT, Scotlandi K, Manara MC, Tape C, Chester K, Anderson J, Fisher J. Fowler D, et al. Sci Transl Med. 2024 May 29;16(749):eadg9814. doi: 10.1126/scitranslmed.adg9814. Epub 2024 May 29. Sci Transl Med. 2024. PMID: 38809963