Boutros T - Search Results

1

Effect of food or proton pump inhibitor treatment on the bioavailability of dacomitinib in healthy volunteers.

Ruiz-Garcia A, Masters JC, Mendes da Costa L, LaBadie RR, Liang Y, Ni G, Ellery CA, Boutros T, Goldberg Z, Bello CL. Ruiz-Garcia A, et al. Among authors: boutros t. J Clin Pharmacol. 2016 Feb;56(2):223-30. doi: 10.1002/jcph.588. Epub 2015 Oct 9. J Clin Pharmacol. 2016. PMID: 26179237 Clinical Trial.

2

The effect of dacomitinib (PF-00299804) on CYP2D6 activity in healthy volunteers who are extensive or intermediate metabolizers.

Bello CL, LaBadie RR, Ni G, Boutros T, McCormick C, Ndongo MN. Bello CL, et al. Among authors: boutros t. Cancer Chemother Pharmacol. 2012 Apr;69(4):991-7. doi: 10.1007/s00280-011-1793-7. Epub 2011 Dec 7. Cancer Chemother Pharmacol. 2012. PMID: 22147075 Clinical Trial.

3

A phase I open-label study to investigate the potential drug-drug interaction between single-dose dacomitinib and steady-state paroxetine in healthy volunteers.

Ruiz-Garcia A, Giri N, LaBadie RR, Ni G, Boutros T, Richie N, Kocinsky HS, Checchio TM, Bello CL. Ruiz-Garcia A, et al. Among authors: boutros t. J Clin Pharmacol. 2014 May;54(5):555-62. doi: 10.1002/jcph.243. Epub 2013 Dec 17. J Clin Pharmacol. 2014. PMID: 24293056 Clinical Trial.

4

Investigation of the impact of hepatic impairment on the pharmacokinetics of dacomitinib.

Giri N, Masters JC, Plotka A, Liang Y, Boutros T, Pardo P, O'Connell J, Bello C. Giri N, et al. Among authors: boutros t. Invest New Drugs. 2015 Aug;33(4):931-41. doi: 10.1007/s10637-015-0256-0. Epub 2015 Jun 6. Invest New Drugs. 2015. PMID: 26048096 Clinical Trial.

5

Evaluation of crizotinib absolute bioavailability, the bioequivalence of three oral formulations, and the effect of food on crizotinib pharmacokinetics in healthy subjects.

Xu H, O'Gorman M, Boutros T, Brega N, Kantaridis C, Tan W, Bello A. Xu H, et al. Among authors: boutros t. J Clin Pharmacol. 2015 Jan;55(1):104-13. doi: 10.1002/jcph.356. Epub 2014 Jul 11. J Clin Pharmacol. 2015. PMID: 24990113 Clinical Trial.

6

Evaluation of Proton Pump Inhibitor Esomeprazole on Crizotinib Pharmacokinetics in Healthy Participants.

Xu H, O'Gorman M, Matschke K, Boutros T, Brega N, Tan W, Bello A. Xu H, et al. Among authors: boutros t. Clin Pharmacol Drug Dev. 2022 Jan;11(1):34-42. doi: 10.1002/cpdd.1032. Epub 2021 Nov 26. Clin Pharmacol Drug Dev. 2022. PMID: 34825782 Free PMC article. Clinical Trial.

7

Assessment of a multiple-dose drug interaction between ezetimibe, a novel selective cholesterol absorption inhibitor and gemfibrozil.

Reyderman L, Kosoglou T, Statkevich P, Pember L, Boutros T, Maxwell SE, Affrime M, Batra V. Reyderman L, et al. Among authors: boutros t. Int J Clin Pharmacol Ther. 2004 Sep;42(9):512-8. doi: 10.5414/cpp42512. Int J Clin Pharmacol Ther. 2004. PMID: 15487810 Clinical Trial.

8

Effects of Renal Function on Crizotinib Pharmacokinetics: Dose Recommendations for Patients with ALK-Positive Non-Small Cell Lung Cancer.

Tan W, Yamazaki S, Johnson TR, Wang R, O'Gorman MT, Kirkovsky L, Boutros T, Brega NM, Bello A. Tan W, et al. Among authors: boutros t. Clin Drug Investig. 2017 Apr;37(4):363-373. doi: 10.1007/s40261-016-0490-z. Clin Drug Investig. 2017. PMID: 28035616

9

Pharmacokinetic interaction between ezetimibe and lovastatin in healthy volunteers.

Reyderman L, Kosoglou T, Boutros T, Seiberling M, Statkevich P. Reyderman L, et al. Among authors: boutros t. Curr Med Res Opin. 2004 Sep;20(9):1493-500. doi: 10.1185/030079904X2547. Curr Med Res Opin. 2004. PMID: 15383199 Clinical Trial.

10

Pharmacodynamic interaction between ezetimibe and rosuvastatin.

Kosoglou T, Statkevich P, Yang B, Suresh R, Zhu Y, Boutros T, Maxwell SE, Tiessen R, Cutler DL. Kosoglou T, et al. Among authors: boutros t. Curr Med Res Opin. 2004 Aug;20(8):1185-95. doi: 10.1185/030079904125004213. Curr Med Res Opin. 2004. PMID: 15324521 Clinical Trial.

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