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A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer.
Wester L, Venneker S, Hazenoot M, Pont C, Koedoot E, Timmermans AM, Martens JWM, Jansen MPHM, Kockx CEM, van IJcken WFJ, Meerman JHN, Zhang Y, van de Water B. Wester L, et al. Among authors: pont c. Biochem Pharmacol. 2022 Oct;204:115233. doi: 10.1016/j.bcp.2022.115233. Epub 2022 Aug 28. Biochem Pharmacol. 2022. PMID: 36041543 Free article.
Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes.
Koedoot E, Fokkelman M, Rogkoti VM, Smid M, van de Sandt I, de Bont H, Pont C, Klip JE, Wink S, Timmermans MA, Wiemer EAC, Stoilov P, Foekens JA, Le Dévédec SE, Martens JWM, van de Water B. Koedoot E, et al. Among authors: pont c. Nat Commun. 2019 Jul 5;10(1):2983. doi: 10.1038/s41467-019-11020-3. Nat Commun. 2019. PMID: 31278301 Free PMC article.
IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer.
Zhang Y, Wester L, He J, Geiger T, Moerkens M, Siddappa R, Helmijr JA, Timmermans MM, Look MP, van Deurzen CHM, Martens JWM, Pont C, de Graauw M, Danen EHJ, Berns EMJJ, Meerman JHN, Jansen MPHM, van de Water B. Zhang Y, et al. Among authors: pont c. Oncogene. 2018 Apr;37(14):1869-1884. doi: 10.1038/s41388-017-0027-9. Epub 2018 Jan 22. Oncogene. 2018. PMID: 29353882
Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells.
de Graauw M, van Miltenburg MH, Schmidt MK, Pont C, Lalai R, Kartopawiro J, Pardali E, Le Dévédec SE, Smit VT, van der Wal A, Van't Veer LJ, Cleton-Jansen AM, ten Dijke P, van de Water B. de Graauw M, et al. Among authors: pont c. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6340-5. doi: 10.1073/pnas.0913360107. Epub 2010 Mar 22. Proc Natl Acad Sci U S A. 2010. PMID: 20308542 Free PMC article.
83 results