He XX - Search Results

1

Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors.

Yu LM, Zhang XR, Li XB, Yang Y, Wei HY, He XX, Gu LQ, Huang ZS, Pommier Y, An LK. Yu LM, et al. Among authors: he xx. Eur J Med Chem. 2015 Aug 28;101:525-33. doi: 10.1016/j.ejmech.2015.07.007. Epub 2015 Jul 8. Eur J Med Chem. 2015. PMID: 26188908 Free PMC article.

2

Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.

Chao X, He X, Yang Y, Zhou X, Jin M, Liu S, Cheng Z, Liu P, Wang Y, Yu J, Tan Y, Huang Y, Qin J, Rapposelli S, Pi R. Chao X, et al. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6498-502. doi: 10.1016/j.bmcl.2012.08.036. Epub 2012 Aug 16. Bioorg Med Chem Lett. 2012. PMID: 22981331

3

Multi-targeted ChEI-copper chelating molecules as neuroprotective agents.

Sestito S, Wang S, Chen Q, Lu J, Bertini S, Pomelli C, Chiellini G, He X, Pi R, Rapposelli S. Sestito S, et al. Eur J Med Chem. 2019 Jul 15;174:216-225. doi: 10.1016/j.ejmech.2019.04.060. Epub 2019 Apr 23. Eur J Med Chem. 2019. PMID: 31042617

4

Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia.

Liang J, Huang YY, Zhou Q, Gao Y, Li Z, Wu D, Yu S, Guo L, Chen Z, Huang L, Liang SH, He X, Wu R, Luo HB. Liang J, et al. J Med Chem. 2020 Mar 26;63(6):3370-3380. doi: 10.1021/acs.jmedchem.0c00060. Epub 2020 Mar 12. J Med Chem. 2020. PMID: 32115956

5

Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.

Huang YY, Deng J, Tian YJ, Liang J, Xie X, Huang Y, Zhu J, Zhu Z, Zhou Q, He X, Luo HB. Huang YY, et al. J Med Chem. 2021 Sep 23;64(18):13736-13751. doi: 10.1021/acs.jmedchem.1c01085. Epub 2021 Sep 14. J Med Chem. 2021. PMID: 34520193

6

The evolution paths of some reprehensive scaffolds of RORγt modulators, a perspective from medicinal chemistry.

Li Z, Liu T, He X, Bai C. Li Z, et al. Eur J Med Chem. 2022 Jan 15;228:113962. doi: 10.1016/j.ejmech.2021.113962. Epub 2021 Nov 1. Eur J Med Chem. 2022. PMID: 34776280 Review.

7

Synthesis and biological evaluation of marine natural product, Cryptoechinuline D derivatives as novel antiangiogenic agents.

Zhu JQ, Fan SR, Wei X, Zhang CX, Zhang DM, Chen MF, He X. Zhu JQ, et al. Bioorg Med Chem Lett. 2022 Jun 1;65:128717. doi: 10.1016/j.bmcl.2022.128717. Epub 2022 Apr 4. Bioorg Med Chem Lett. 2022. PMID: 35390450

8

Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases.

Liu H, Wang Q, Huang Y, Deng J, Xie X, Zhu J, Yuan Y, He YM, Huang YY, Luo HB, He X. Liu H, et al. Eur J Med Chem. 2022 Nov 15;242:114631. doi: 10.1016/j.ejmech.2022.114631. Epub 2022 Aug 9. Eur J Med Chem. 2022. PMID: 35985255

9

New Indole Diketopiperazine Alkaloids from Soft Coral-Associated Epiphytic Fungus Aspergillus versicolor CGF 9-1-2.

Hu JS, He YP, Zhou FG, Wu PP, Chen LY, Ni C, Zhang ZK, Xiao XJ, An LK, He XX, Zhang CX. Hu JS, et al. Among authors: he xx, he yp. Chem Biodivers. 2023 Jun;20(6):e202300301. doi: 10.1002/cbdv.202300301. Epub 2023 May 17. Chem Biodivers. 2023. PMID: 37097072

10

Moracin M from Morus alba L. is a natural phosphodiesterase-4 inhibitor.

Chen SK, Zhao P, Shao YX, Li Z, Zhang C, Liu P, He X, Luo HB, Hu X. Chen SK, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3261-4. doi: 10.1016/j.bmcl.2012.03.026. Epub 2012 Mar 21. Bioorg Med Chem Lett. 2012. PMID: 22483586

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