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C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation.
Lall D, Lorenzini I, Mota TA, Bell S, Mahan TE, Ulrich JD, Davtyan H, Rexach JE, Muhammad AKMG, Shelest O, Landeros J, Vazquez M, Kim J, Ghaffari L, O'Rourke JG, Geschwind DH, Blurton-Jones M, Holtzman DM, Sattler R, Baloh RH. Lall D, et al. Neuron. 2021 Jul 21;109(14):2275-2291.e8. doi: 10.1016/j.neuron.2021.05.020. Epub 2021 Jun 15. Neuron. 2021. PMID: 34133945 Free PMC article.
Breakdown of the central synapses in C9orf72-linked ALS/FTD.
Ghaffari LT, Trotti D, Haeusler AR, Jensen BK. Ghaffari LT, et al. Front Mol Neurosci. 2022 Sep 16;15:1005112. doi: 10.3389/fnmol.2022.1005112. eCollection 2022. Front Mol Neurosci. 2022. PMID: 36187344 Free PMC article. Review.