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Page 1
Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
Walsh SP, Shahripour A, Tang H, Teumelsan N, Frie J, Zhu Y, Priest BT, Swensen AM, Liu J, Margulis M, Visconti R, Weinglass A, Felix JP, Brochu RM, Bailey T, Thomas-Fowlkes B, Alonso-Galicia M, Zhou X, Pai LY, Corona A, Hampton C, Hernandez M, Bentley R, Chen J, Shah K, Metzger J, Forrest M, Owens K, Tong V, Ha S, Roy S, Kaczorowski GJ, Yang L, Parmee E, Garcia ML, Sullivan K, Pasternak A. Walsh SP, et al. Among authors: corona a. ACS Med Chem Lett. 2015 May 7;6(7):747-52. doi: 10.1021/ml500440u. eCollection 2015 Jul 9. ACS Med Chem Lett. 2015. PMID: 26191360 Free PMC article.
Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.
Tang H, Zhu Y, Teumelsan N, Walsh SP, Shahripour A, Priest BT, Swensen AM, Felix JP, Brochu RM, Bailey T, Thomas-Fowlkes B, Pai LY, Hampton C, Corona A, Hernandez M, Metzger J, Forrest M, Zhou X, Owens K, Tong V, Parmee E, Roy S, Kaczorowski GJ, Yang L, Alonso-Galicia M, Garcia ML, Pasternak A. Tang H, et al. Among authors: corona a. ACS Med Chem Lett. 2016 May 12;7(7):697-701. doi: 10.1021/acsmedchemlett.6b00122. eCollection 2016 Jul 14. ACS Med Chem Lett. 2016. PMID: 27437080 Free PMC article.
The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.
Chobanian HR, Guo Y, Pio B, Tang H, Teumelsan N, Clements M, Frie J, Ferguson R, Guo Z, Thomas-Fowlkes BS, Felix JP, Liu J, Kohler M, Priest B, Hampton C, Pai LY, Corona A, Metzger J, Tong V, Joshi EM, Xu L, Owens K, Maloney K, Sullivan K, Pasternak A. Chobanian HR, et al. Among authors: corona a. Bioorg Med Chem Lett. 2017 Feb 15;27(4):1109-1114. doi: 10.1016/j.bmcl.2016.10.032. Epub 2016 Oct 13. Bioorg Med Chem Lett. 2017. PMID: 28111141
The Renal Outer Medullary Potassium Channel Inhibitor, MK-7145, Lowers Blood Pressure, and Manifests Features of Bartter's Syndrome Type II Phenotype.
Hampton C, Zhou X, Priest BT, Pai LY, Felix JP, Thomas-Fowlkes B, Liu J, Kohler M, Xiao J, Corona A, Price O, Gill C, Shah K, Rasa C, Tong V, Owens K, Ormes J, Tang H, Roy S, Sullivan KA, Metzger JM, Alonso-Galicia M, Kaczorowski GJ, Pasternak A, Garcia ML. Hampton C, et al. Among authors: corona a. J Pharmacol Exp Ther. 2016 Oct;359(1):194-206. doi: 10.1124/jpet.116.235150. Epub 2016 Jul 18. J Pharmacol Exp Ther. 2016. PMID: 27432892
Effects of Chlorpyrifos on gut dysbiosis and barriers integrity in women with a focus on pregnancy and prebiotic intervention: Insights from advanced in vitro human models.
Abou Diwan M, Huet A, Poiriez J, Joly Condette C, Delanaud S, Sevin E, Corona A, Rhazi L, Depeint F, Ouadid-Ahidouch H, Gosselet F, Bach V, Candela P, Khorsi-Cauet H. Abou Diwan M, et al. Among authors: corona a. Environ Pollut. 2024 Dec 13;367:125533. doi: 10.1016/j.envpol.2024.125533. Online ahead of print. Environ Pollut. 2024. PMID: 39674256
Dynamic CRRT Prescription for Complicated Critically Ill Patient: A Case Report.
Santorsola C, Corona A, Cecchi M, Nicolini NC, Zendra E, Capone A, Gatti I, Brivio M, Falsini S, Villa G. Santorsola C, et al. Among authors: corona a. Case Rep Crit Care. 2024 Nov 20;2024:1837150. doi: 10.1155/2024/1837150. eCollection 2024. Case Rep Crit Care. 2024. PMID: 39611098 Free PMC article.
The clock is ticking on schizophrenia: a study protocol for a translational study integrating phenotypic, genomic, microbiome and biomolecular data to overcome disability.
Mercuriali G, Lodde L, Paribello P, Sapienza J, Corona A, Ave C, Pacini D, Nocera D, Corrias C, El Kacemi S, D'Incalci M, Frau I, Monzani E, Valtorta F, Congiu D, Meloni A, Scherma M, Fadda P, Dedoni S, Siddi C, Sut S, Dall'Acqua S, Nasini S, Barzon B, Squassina A, Cavallaro R, Manchia M, Pisanu C, Bosia M, Comai S. Mercuriali G, et al. Among authors: corona a. Front Psychiatry. 2024 Oct 30;15:1451678. doi: 10.3389/fpsyt.2024.1451678. eCollection 2024. Front Psychiatry. 2024. PMID: 39540006 Free PMC article.
Expanding the Solvent/Protein Region Occupation of the Non-Nucleoside Reverse Transcriptase Inhibitor Binding Pocket for Improved Broad-Spectrum Anti-HIV-1 Efficacy: from Rigid Phenyl-Diarylpyrimidines to Flexible Hydrophilic Piperidine-Diarylpyrimidines.
Huang WJ, Pannecouque C, De Clercq E, Corona A, Maloccu S, Tramontano E, Wang S, Chen FE. Huang WJ, et al. Among authors: corona a. J Med Chem. 2024 Nov 14;67(21):19889-19904. doi: 10.1021/acs.jmedchem.4c02413. Epub 2024 Nov 5. J Med Chem. 2024. PMID: 39498544
347 results