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Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury.
Sweigard JH, Matsumoto H, Smith KE, Kim LA, Paschalis EI, Okonuki Y, Castillejos A, Kataoka K, Hasegawa E, Yanai R, Husain D, Lambris JD, Vavvas D, Miller JW, Connor KM. Sweigard JH, et al. Among authors: lambris jd. Sci Transl Med. 2015 Jul 22;7(297):297ra116. doi: 10.1126/scitranslmed.aab1482. Sci Transl Med. 2015. PMID: 26203084 Free PMC article.
Unwelcome complement.
Markiewski MM, Lambris JD. Markiewski MM, et al. Among authors: lambris jd. Cancer Res. 2009 Aug 15;69(16):6367-70. doi: 10.1158/0008-5472.CAN-09-1918. Epub 2009 Aug 4. Cancer Res. 2009. PMID: 19654288 Free PMC article. Review.
Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates.
Hughes S, Gumas J, Lee R, Rumano M, Berger N, Gautam AK, Sfyroera G, Chan AL, Gnanaguru G, Connor KM, Kim BJ, Dunaief JL, Ricklin D, Hajishengallis G, Yancopoulou D, Reis ES, Mastellos DC, Lambris JD. Hughes S, et al. Among authors: lambris jd. Clin Immunol. 2020 May;214:108391. doi: 10.1016/j.clim.2020.108391. Epub 2020 Mar 27. Clin Immunol. 2020. PMID: 32229292 Free PMC article.
Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function.
Cerniauskas E, Kurzawa-Akanbi M, Xie L, Hallam D, Moya-Molina M, White K, Steel D, Doherty M, Whitfield P, Al-Aama J, Armstrong L, Kavanagh D, Lambris JD, Korolchuk VI, Harris C, Lako M. Cerniauskas E, et al. Among authors: lambris jd. Stem Cells Transl Med. 2020 Dec;9(12):1585-1603. doi: 10.1002/sctm.20-0211. Epub 2020 Aug 20. Stem Cells Transl Med. 2020. PMID: 32815311 Free PMC article.
523 results